The Immunosuppressive Niche of Soft Tissue Sarcomas is Sustained by Tumor Associated Macrophages and Characterized by Intratumoral Tertiary Lymphoid Structures.

CONCLUSIONS: Our work in STS revealed an immunosuppressive TME dominated by myeloid cells, which may be overcome with activation of T-cells that traffic into the tumor. In RMS, targeting T-cells found within TLS may be key to achieve anti-tumor response.
PMID: 32332015 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - April 23, 2020 Category: Cancer & Oncology Authors: Chen L, Oke T, Siegel N, Cojocaru G, Tam AJ, Blosser RL, Swailes J, Ligon JA, Lebid A, Morris C, Levin A, Rhee DS, Johnston FM, Greer JB, Meyer CF, Ladle BH, Thompson ED, Montgomery EA, Choi W, McConkey DJ, Anders RA, Pardoll DM, Llosa NJ Tags: Clin Cancer Res Source Type: research