Direct oral anticoagulant plasma levels striking increase in severe COVID-19 respiratory syndrome patients treated with antiviral agents. The Cremona experience.

CONCLUSION: DOAC patients treated with antiviral drugs show an alarming increase in DOAC plasma levels. In order to prevent bleeding complications, we believe that physicians should consider withholding DOACs from patients with SARS-CoV-2 and replacing them with alternative parenteral antithrombotic strategies for as long as antiviral agents are deemed necessary and until discharge. PMID: 32329231 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32329231?dopt=Abstract

Source: Thrombosis and Haemostasis - April 22, 2020 Category: Hematology Authors: Testa S, Prandoni P, Paoletti O, Morandini R, Tala M, Dellanoce C, Giorgi-Pierfranceschi M, Betti M, Danzi GB, Pan A, Palareti G Tags: J Thromb Haemost Source Type: research