Weekly Roundup – December 6, 2013

Happy Friday! It has been a while since the roundup ran on a Friday; we were trying different days to see what our fabulous readers preferred. If you have a preference let us know. Does hormone replacement therapy help aging women’s moods and mental agility? The Los Angeles Times ran an article on a study that says it is not helpful, read the article for more on this study as well as a few others that are in the works. A study recently published in the New England Journal of Medicine found that vaccination programs for children have prevented more than 100 million cases of serious contagious disease in the United States since 1924. The researchers believe the data should help inform the debate on the risks and benefits of vaccinating children. To learn more on this study and the availability of its data read the New York Times article. According to research discussed in a USAToday article the activation of the immune system seems to cause not just physical ailments, but mental ones as well.  The addition of immune system inflammation has helped neuroscientists cast a broader net when searching for causes of and possible treatments for mental illness, mood disorders and neurodevelopmental conditions. Kaiser Health News ran an article on how more hospitals around the country are starting palliative care programs. These programs are designed to relieve seriously ill patients’ pain, stress and symptoms regardless of how long they have to live. They are important ...
Source: Disruptive Women in Health Care - Category: Health Medicine and Bioethics Commentators Authors: Tags: Roundup Columbia University Columbia University Mailman School of Public Health Kaiser Health News Los Angeles Times new york times Palliative care USA Today usatoday Source Type: blogs

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Publication date: October 2018Source: The Lancet Neurology, Volume 17, Issue 10Author(s): The Lancet Neurology
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: October 2018Source: The Lancet Neurology, Volume 17, Issue 10Author(s): Nicholas D James, Stephen B McMahon, Edelle C Field-Fote, Elizabeth J BradburySummaryNeuromodulation, the use of electrical interfaces to alter neuronal activity, has been successful as a treatment approach in several neurological disorders, including deep brain stimulation for Parkinson's disease and epidural spinal stimulation for chronic pain. Neuromodulation can also be beneficial for spinal cord injury, from assisting basic functions such as respiratory pacing and bladder control, through to restoring volitional movements and ski...
Source: The Lancet Neurology - Category: Neurology Source Type: research
ConclusionsThe chemical and biological properties of SO, SP and SG were different and distinctive. They might be reasonably applied in clinic for the management of rheumatism/-related diseases.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: Our results demonstrate that Eta-induced antinociception and anti-inflammatory effects occur by TRPA1 inhibition making possible the use of this preparation as a potential therapeutic agent to treat pathological pains.Graphical Abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
AbstractNonsteroidal anti-inflammatory drugs are commonly used worldwide; however, they have several adverse effects, evidencing the need for the development of new, more effective and safe anti-inflammatory and analgesic drugs. This research aimed to design, synthesize and carry out a pharmacological/toxicological investigation of LQFM-102, which was designed from celecoxib and paracetamol by molecular hybridization. To evaluate the analgesic effect of this compound, we performed formalin-induced pain, hot plate and tail flick tests. The anti-inflammatory effect of LQFM-102 was evaluated in carrageenan-induced paw oedema ...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsA Jintronix-based therapy demonstrated good acceptability and safety in hospitalized burn patients. Feedback from this study led to software modifications implemented by the Jintronix company. This feasibility study has informed the design of a prospective randomized controlled trial to determine whether a virtual-environment home rehabilitation strategy improves functional outcomes after burn injury.
Source: Burns - Category: Dermatology Source Type: research
(MedPage Today) -- Findings from meta-analysis of human lab studies
Source: MedPage Today Neurology - Category: Neurology Source Type: news
Publication date: 18 September 2018Source: Cell Reports, Volume 24, Issue 12Author(s): Girish Bankar, Samuel J. Goodchild, Sarah Howard, Karen Nelkenbrecher, Matthew Waldbrook, Michelle Dourado, Noah G. Shuart, Sophia Lin, Clint Young, Zhiwei Xie, Kuldip Khakh, Elaine Chang, Luis E. Sojo, Andrea Lindgren, Sultan Chowdhury, Shannon Decker, Michael Grimwood, Jean-Christophe Andrez, Christoph M. Dehnhardt, Jodie PangSummarySelective block of NaV1.7 promises to produce non-narcotic analgesic activity without motor or cognitive impairment. Several NaV1.7-selective blockers have been reported, but efficacy in animal pain models ...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 18 September 2018Source: Cell Reports, Volume 24, Issue 12Author(s): Kia C.E. Walcott, Stephanie E. Mauthner, Asako Tsubouchi, Jessica Robertson, W. Daniel TraceySummaryInhibition of nociceptor activity is important for the prevention of spontaneous pain and hyperalgesia. To identify the critical K+ channels that regulate nociceptor excitability, we performed a forward genetic screen using a Drosophila larval nociception paradigm. Knockdown of three K+ channel loci, the small conductance calcium-activated potassium channel (SK), seizure, and tiwaz, causes marked hypersensitive nociception behaviors. In mo...
Source: Cell Reports - Category: Cytology Source Type: research
Drugs derived from an active ingredient in marijuana produced only modest increases in pain threshold and tolerance but no reduction in ongoing intensity.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
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