Neuromodulation of memory formation and extinction.

Neuromodulation of memory formation and extinction. Curr Neurovasc Res. 2020 Apr 21;: Authors: Bostancıklıoğlu M Abstract Memory retrieval is mediated by discharges of acetylcholine, glutamate, gamma-aminobutyric acid, norepinephrine, and serotonin/5-hydroxytryptamine circuits. These projections and memory interact through engram circuits, neurobiological traces of memory. Increased excitability in engram circuits of medial prefrontal cortex and hippocampus results in remote and recent memory retrievals, respectively. However, due to degenerated neurotransmitter projections, the excitability state of engram circuits is decreased in the patient with dementia; and thus, acquired-memory cannot be retrieved by natural cues. Here we suggest that artificial neuropharmacological stimulations of the acquired-memory with an excitation potential higher than a natural cue can excite engram circuits in the medial prefrontal cortex, which results in the retrieval of lost memories in dementia. Also, we explained the neuropharmacological foundations of engram cell-mediated memory retrieval strategy in severe dementia, in line with this, we particularly highlighted the close interactions between periaqueductal gray, locus coeruleus, raphe nuclei, and medial prefrontal cortex and basolateral amygdala as treatment targets for memory loss. Furthermore, the engram circuits projecting raphe nuclei, locus coeruleus, and pontomesencephalic tegmentum complex could be signifi...
Source: Current Neurovascular Research - Category: Neurology Authors: Tags: Curr Neurovasc Res Source Type: research

Related Links:

Dementia is a syndrome and an umbrella term that encompasses Alzheimer, Parkinson and autism diseases. These diseases are by far the most common cause of dementia; therefore this investigation will chiefly include these disorders, with a limited discussion of few other disorders related to dementia. Alzheimer’s disease (AD) is characterized by the accumulation of cerebral β-amyloid plaques, tau proteins and memory loss; Parkinson by the deterioration of brain cells which regulate the movement of body parts and produce dopamine; and autism by abnormalities of social disorder and difficulty in communicating and fo...
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
DEMENTIA symptoms include memory loss, difficulty concentrating, and having slower thoughts. But, you could lower your risk of developing Alzheimer's disease signs with this simple breakfast swap. Should you change the foods you eat to protect against dementia?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
DEMENTIA symptoms include memory loss, difficulty concentrating, and having slower thoughts. But, you could lower your risk of developing Alzheimer's disease with this "single most important" diet swap. Should you change the foods you eat to protect against dementia?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
We report that short-term exposure to a high-cholesterol diet led to decreased thigmotaxis and short-term spatial memory impairment without affecting long-term recognition memory. Furthermore, cognitive and behavioral phenotypes in these mice were associated with a reduction in interleukin-15 levels in the absence of changes in other inflammatory mediators. Our findings indicate that interleukin-15 may play a role in early stages of cognitive impairment secondary to hypercholesterolemia. Consequently, optimization of interleukin-15 signaling may be a viable effective cognitive therapy in the population susceptible to devel...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
CONCLUSION: In summary, the transdermal administration of Alzheimer's drugs is an interesting and promising topic, which should be further elaborated. PMID: 32552655 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research
DEMENTIA symptoms include memory loss, difficulty concentrating, and having slower thoughts. But, you could lower your risk of developing Alzheimer's disease if you add this cheap fruit to your daily diet.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
DEMENTIA symptoms include difficulty concentrating, mood changes, and having slower thoughts. But, you could also be at risk of Alzheimer's disease if you develop memory loss. When should you consider speaking to a doctor about Alzheimer's disease symptoms and declining memory?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
DEMENTIA symptoms can be difficult to spot in its early stages, although there are a number of warning signs to look out for - including memory loss. These are the five most common early symptoms of Alzheimer's disease. Should you speak to a doctor about your dementia risk?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
DEMENTIA symptoms include memory loss, difficulty concentrating, and having slower thoughts. But, you could also be at risk of Alzheimer's disease if you develop this subtle sign with your bad language. Should you consider speaking to a doctor about Alzheimer's disease symptoms?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
More News: Alzheimer's | Amnesia | Brain | Dementia | Neurology | Study