A Fully Automatic Method for Optic Radiation Tractography Applicable to Multiple Sclerosis Patients.

A Fully Automatic Method for Optic Radiation Tractography Applicable to Multiple Sclerosis Patients. Brain Topogr. 2020 Apr 17;: Authors: Davion JB, Kuchcinski G, Viard R, Dumont J, Pruvo JP, Leclerc X, Outteryck O, Lopes R Abstract The optic radiations (OR) are white matter tracts forming the posterior part of the visual ways. As an important inter-individual variability exists, atlases may be inefficient to locate the OR in a given subject. We designed a fully automatic method to delimitate the OR on a magnetic resonance imaging using tractography. On 15 healthy subjects, we evaluated the validity of our method by comparing the outputs to the Jülich post-mortem histological atlas, and its reproducibility. We also evaluated its feasibility on 98 multiple sclerosis (MS) patients. We correlated different visual outcomes with the inflammatory lesions volume within the OR reconstructed with different methods (our method, atlas, TractSeg). Our method reconstructed the OR bundle in all healthy subjects (< 2 h for most of them), and was reproducible. It demonstrated good classification indexes: sensitivity up to 0.996, specificity up to 0.993, Dice coefficient up to 0.842, and an area under the receiver operating characteristic (ROC) curve of 0.981. Our method reconstructed the OR in 91 of the 98 MS patients (92.9%, < 6 h for most of patients). Compared to an atlas-based approach and the TractSeg method, the inflammatory les...
Source: Brain Topography - Category: Neuroscience Authors: Tags: Brain Topogr Source Type: research