Valproic Acid Reduces Neuritic Plaque Formation and Improves Learning Deficits in APP(Swe) /PS1(A246E) Transgenic Mice via Preventing the Prenatal Hypoxia-Induced Down-Regulation of Neprilysin.

CONCLUSION: Valproic acid is able to attenuate the prenatal hypoxia-induced Aβ neuropathology and learning and memory deficits via inhibiting the activation of histone deacetylase 1 (HDAC1), preventing the decrease in H3-Ace in the NEP promoter regions and reducing the down-regulation of NEP. PMID: 24289518 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research