Valproic Acid Reduces Neuritic Plaque Formation and Improves Learning Deficits in APP(Swe) /PS1(A246E) Transgenic Mice via Preventing the Prenatal Hypoxia-Induced Down-Regulation of Neprilysin.
CONCLUSION: Valproic acid is able to attenuate the prenatal hypoxia-induced Aβ neuropathology and learning and memory deficits via inhibiting the activation of histone deacetylase 1 (HDAC1), preventing the decrease in H3-Ace in the NEP promoter regions and reducing the down-regulation of NEP.
PMID: 24289518 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Wang Z, Zhang XJ, Li T, Li J, Tang Y, Le W Tags: CNS Neurosci Ther Source Type: research
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