Quantitative evaluation of subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus by three-dimensional echocardiography

This study aimed to quantify LV myocardial strain and synchrony in T2DM by real-time three-dimensional echocardiography (RT-3DE), and to evaluate subclinical LV dysfunction in T2DM at different glycemic control levels. Seventy-two patients with T2DM with an LV ejection fraction (LVEF)  ≥ 55% and 45 healthy individuals as controls who underwent RT-3DE were studied. Patients were also subdivided into the DMa group (glycosylated hemoglobin <  7%, n = 38) and the DMb group (glycosylated hemoglobin ≥ 7%, n = 34). Three-dimensional strain and synchronization parameters of the left ventricle were measured by RT-3DE and compared among the three groups. Despite a similar LVEF, global longitudinal strain (GLS), global circumfer ential strain (GCS), and global area strain (GAS) in the DMb group were lower, and the standard deviation of peak time (Tm-SD) and the maximum difference in peak time (Tm-Dif) in the DMb group higher, than those in the control and DMa groups (allp <  0.05). Multivariable linear regression analysis showed that the duration of diabetes was independently associated with GCS (β =  − 0.516,p <  0.001) and GAS (β =  − 0.391,p = 0.005). HbA1c levels were independently associated with GLS (β =  − 0.675,p <  0.001), Tm-SD (β = 3.363, p <  0.001), and Tm-Dif (β = 3.895, p <  0.001). RT-3DE can detect subclinical myocardial dysfunction in poor glycemic control of T2...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research