Study of Cytogenetic Alterations and Association With Prognostic Factors in Indian Children With B-Lineage Acute Lymphoblastic Leukemia

The most common cytogenetic alteration was high hyperdiploidy (13.0%). ETV6-RUNX1 translocation occurred in 5.2% of children with ALL; BCR-ABL1 translocation occurred in 12.2%. Hypodiploidy was not seen in any patient. Children with poor-risk cytogenetic alterations had significantly lower event-free survival as compared with those with good- or intermediate-risk cytogenetic alterations (p  = 0.0029).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research