Discrimination Between Atopic, Allergic, and Asthmatic Volunteers for Human Exposure Studies on Sensory Irritation.

Discrimination Between Atopic, Allergic, and Asthmatic Volunteers for Human Exposure Studies on Sensory Irritation. Adv Exp Med Biol. 2020 Apr 08;: Authors: van Kampen V, Hoffmeyer F, Monsé C, Raulf M, Brüning T, Bünger J, Sucker K Abstract Atopic, allergic, and especially asthmatic subjects might be particularly susceptible to sensory irritation induced by airborne chemicals compared to healthy individuals. Therefore, a good characterization of subjects is essential in inhalation exposure studies on sensory irritants. A total of 105 volunteers, 87% of whom reported to be non-allergic, participated in a medical examination that included skin prick test (SPT), measurements of total IgE, specific IgE (sIgE) to an ubiquitous allergen mix (sx1), and fractionated exhaled nitric oxide (FeNO), as well as pulmonary function and methacholine test. The median value of sIgE to sx1 was 0.20 kU/L (0.07-91.3 kU/L) and correlated significantly with total IgE (28.8 kU/L (2-756 kU/L)) and FeNO (14 ppb (5-100 ppb)). Forty-three subjects (41%) had sIgE to sx1 ≥ 0.35 kU/L and were classified as atopic. Thirty-five subjects, all also sx1-positive, were positive in SPT. Obstruction, small airway disease, and/or bronchial hyperreactivity were diagnosed in 18 subjects. Receiver operating characteristics (ROC) were performed to check whether signs of sensitization are useful to discriminate subjects with and without...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research

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The 2020 Members of Proficiency Standards for Pulmonary Function Testing Committee of the American Thoracic Society recently raised concerns on pulmonary function testing (PFT) “as a potential avenue for COVID 19 transmission due to the congregation of patients with lung disease and because of the potential for coughing and droplet formation”. (1) The Committee reccommen-ded that “PFT be limited to tests that are only essential for immediate treatment decisions” an d that “personal protective equipment (PPE) for healthcare workers should be discussed with local infe-ction control team”.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Conclusions: There was increased burden of respiratory problems and lower lung volumes and flows among traffic policemen.
Source: Indian Journal of Community Medicine - Category: International Medicine & Public Health Authors: Source Type: research
CONCLUSION: Racial differences persisted in this cohort through age 10 years. Future studies should include potentially important, but rarely studied factors such as segregation and structural racism as these factors could explain the observed racial differences. PMID: 31945477 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
es MA Abstract BACKGROUND: The assessment of airway function in preschool children can be done using simple measurement techniques such as interrupter resistance (Rint) or specific airway resistance (sRaw). OBJECTIVE: The aim of the study was to assess the relationship and the agreement between Rint and sRaw baseline measurements expressed in z-score and Bronchodilator Response (BDR) in accordance with the latest reference equations and recommended procedures. METHODS: One hundred thirty children aged 3 to 6 years old, referred to our Pediatric Pulmonary Function Test unit for assessment of airway functi...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
CONCLUSION: Once-daily tiotropium as add-on therapy is efficacious and safe in adolescents and children with moderate-to-severe asthma. These results support the expanded indication by regulatory authorities for add-on tiotropium in patients aged ≥6 years. PMID: 31805357 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
Authors: Liao PC, Lin HH, Chiang BL, Lee JH, Yu HH, Lin YT, Yang YH, Li PY, Wang LC, Sun WZ Abstract Background: Tai Chi Chuan (TCC) is an exercise of low to moderate intensity with key features of mindfulness, structural alignment, and flexibility to relax the body and mind in adults. Our previous study showed that TCC could improve the quality of life (QoL), pulmonary function, and fractional exhaled nitric oxide in asthmatic children. We further investigated whether the benefits induced by TCC were associated with immune regulation. Method: Six- to twelve-year-old children diagnosed with mild to severe persi...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
We examined 69 consecutive asthmatics (73.4 ± 6.1 years). The Kihon Checklist questionnaire is used as a screening tool for identifying frail individuals. The participants completed pulmonary function tests and the following PROs: the Asthma Quality of Life Questionnaire (AQLQ), the Asthma Control Test (ACT), the Hyland Scale, the Dyspnea-12 (D-12) and the Adherence Starts with Knowledge-20 (ASK-20).Results: According to total score of the Kihon Checklist, 38 (55.1%), 21 (30.4%), 10 (14.5%) subjects were classified as robust, prefrail and frail. VC(L), FVC(L), FEV1(L), TLC(L), RV/TLC(%) and DLCO(% pred) were weakly ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Severe asthma (SA) affects 5% of asthmatics. Asthma control test (ACT) and GINA control questionnaire (GINAq) are useful clinical scores (CS) to evaluate asthma control. Information about the relationship among CS, FeNO and pulmonary function tests in asthma control assessment, is scarce.Objectives: to assess the performance of FeNO, impulse oscilometry (IO) and spirometry vs. CS on asthma control assessment, in SA children.Methods: 12 months, multicentric, prospective, cross-sectional study. All SA patients (according GINA guidelines) were included (n=81). In reference to CS, uncontrolled asthma was defined by ACT ≤19....
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric asthma and allergy Source Type: research
Conclusion: Benralizumab treatment strongly reduces basophils in patients with severe asthma, suggesting that the effects of Benralizumab in severe asthma might not be restricted to the depletion of eosinophils. Funding: This investigator-initiated study was funded by AstraZeneca (ESR-16-124 73).
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Several studies have shown that low serum levels of Vitamin D are linked to impaired lung function (Cassim, R., et al., Allergy, 2015. 70(4): p. 339-54.). Vitamin D may affect the course of asthma by effects such as anti-inflammatory effect, prevention of respiratory infections and reduction of steroid resistance (Iqbal, et al. J Investig Med, 2011. 59(8): p. 1200-2.). 35 healthy controls and 60 patients with asthma were included in the study between December 2016 and February 2017. Demographic characteristics and pulmonary function tests (PFT) were recorded and laboratory tests were measured. Asthma control test (ACT) was...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
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