TGF- β1 +869C/T polymorphism increases susceptibility to rheumatoid arthritis in North Indian population

ConclusionsTGF- β1 polymorphism is associated with disease activity of RA. Disease activity is strongly modulated in the presence of serum RF and TGF-β1 polymorphism.Key Points•TGF-β1 +869C/T polymorphism was found to be associated with RA in the patients.•The polymorphism showed significant association with all inflammatory parameters as ESR, CRP, and DAS-28 in RA subjects.•RF negative patients showed high ESR, CRP, and swollen joint count with TT genotype.•TGF-β1 polymorphism and serum RF are modulating disease activity in RA.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research