The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens [Biochemistry]

A significant fraction of the glycerophospholipids in the human body is composed of plasmalogens, particularly in the brain, cardiac, and immune cell membranes. A decline in these lipids has been observed in such diseases as Alzheimer’s and chronic obstructive pulmonary disease. Plasmalogens contain a characteristic 1-O-alk-1′-enyl ether (vinyl ether) double...

Source: Proceedings of the National Academy of Sciences - April 6, 2020 Category: Science Authors: Ernst R. Werner, Markus A. Keller, Sabrina Sailer, Katharina Lackner, Jakob Koch, Martin Hermann, Stefan Coassin, Georg Golderer, Gabriele Werner-Felmayer, Raphael A. Zoeller, Nicolas Hulo, Johannes Berger, Katrin Watschinger Tags: Biological Sciences Source Type: research