The price and value of impantable cardioverter defibrillators in hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) came to prominence in 1958 when Donald Teare described in the British Heart Journal its typical pathological features in 8 patients who died suddenly. The excessive risk of sudden cardiac death (SCD) dominated the early literature and contemporary 21st century studies suggest that the SCD rate is approximately 1% per year [1]. Ventricular arrhythmias are the primary cause of SCD and the development of the implantable cardioverter defibrillator (ICD) in 1980 was a significant milestone.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research

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Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: EDITORIAL ‐ INVITED Source Type: research
Obscurin is a giant cytoskeletal protein with structural and regulatory roles encoded by the OBSCN gene. Recently, mutations in OBSCN were associated with the development of different forms of cardiomyopathies, including hypertrophic cardiomyopathy (HCM). We previously reported that homozygous mice carrying the HCM-linked R4344Q obscurin mutation develop arrhythmia by 1-year of age under sedentary conditions characterized by increased heart rate, frequent incidents of premature ventricular contractions, and episodes of spontaneous ventricular tachycardia. In an effort to delineate the molecular mechanisms that contribute t...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions BBs differ within the class in so many ways that it is not only logical but also practical for real-life clinical practice that experts in the field make a list of the compelling indications for individual BBs. Time has come to incorporate our knowledge about BBs into a new approach of presenting these useful and very individual drugs. PMID: 32418526 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
ConclusionIn this study, CSD was effective for treatment of VAs in patients with structural heart disease refractory to antiarrhythmic drugs and catheter ablation. Further larger studies are required to confirm these findings.Graphic abstract
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
AbstractPurpose of ReviewThis review summarizes the evidence concerning the imaging techniques and features to (a) diagnose and (b) risk stratify patients with, or at risk of, inherited cardiomyopathies. The inherited cardiomyopathies we have focused on are dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM) and arrhythmogenic cardiomyopathies (arrhythmogenic right ventricular cardiomyopathy (AVRC), arrhythmogenic left ventricular cardiomyopathy (ALVC) and noncompaction cardiomyopathy (NCCM)).Recent FindingsEchocardiogram and cardiac magnetic resonance imaging (CMR) still form the foundations of the diagnosis a...
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
Hypertrophic cardiomyopathy (HCM) came to prominence in 1958 when Donald Teare described in the British Heart Journal its typical pathological features in 8 patients who died suddenly. The excessive risk of sudden cardiac death (SCD) dominated the early literature and contemporary 21st century studies suggest that the SCD rate is approximately 1% per year [1]. Ventricular arrhythmias are the primary cause of SCD and the development of the implantable cardioverter defibrillator (ICD) in 1980 was a significant milestone.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
Discussion Tachycardia is a rapid heart rate that is above normal for age and level of exertion. Tachycardia is common, particularly sinus tachycardia due to normally encountered circumstances such as pain, fever or exercise. It is usually a normal physiologic process but sustained tachycardia often indicates a potentially abnormal underlying cause. Sinus tachycardia has a rapid heart rate with normal P waves and P-R intervals and variations from moment to moment and respiration. Generally it is not over 200 beats/minute. Vagal stimulation can slow the heart rate; this is a gradual slowing, not an abrupt slowing seen in ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
AbstractHypertrophic cardiomyopathy (HCM) is a genetic cardiomyopathy with a wide spectrum of clinical manifestations. Patients can be asymptomatic or suffer major adverse events including sudden cardiac death, ventricular arrhythmias, and heart failure. Identification of individuals with HCM who are at risk for these complications remains challenging. While echocardiography remains the mainstay of diagnostic evaluation, cardiac magnetic resonance imaging (CMR) is an important adjunctive diagnostic modality with emerging applications for risk-stratification of adverse events in the HCM population. Although not included in ...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
Abstract Objectives: To examine the association between the echocardiographic parameters measured as left atrial diameter (LAD) and left ventricular end-diastolic diameter (LVEDD) and long-term risk of all-cause mortality in adults with hypertrophic cardiomyopathy (HCM) following pacemaker implantation. Methods: A total of 94 adult patients with HCM who underwent pacemaker implantation from November 2002 to June 2013 in our Arrhythmia Center for symptomatic bradycardia and did not receive an implantable cardiac defibrillator (ICD) or cardiac resynchronization therapy (CRT) during follow-up were retrospectivel...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
Conclusions: Our data suggest that integrin β1D deficiency represents a novel mechanism underlying the increased risk of ventricular arrhythmias in patients with ARVC. PMID: 32122157 [PubMed - as supplied by publisher]
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
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