Involvement of Inflammasome Activation in Lipopolysaccharide-induced Mice Depressive-like Behaviors.

CONCLUSION: These data suggest for the first time that the NLRP3 inflammasome is involved in lipopolysaccharide-induced mice depressive-like behaviors. The NLRP3 inflammasome may be a central mediator between immune activation and depression, which raises the possibility that it may be a more specific target for the depression treatments in the near future.
PMID: 24279434 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Zhang Y, Liu L, Peng YL, Liu YZ, Wu TY, Shen XL, Zhou JR, Sun DY, Huang AJ, Wang X, Wang YX, Jiang CL Tags: CNS Neurosci Ther Source Type: research