Clinical characteristics and risk factors of drug ‐induced lung injury by ALK tyrosine kinase inhibitors: A single center retrospective analysis

ConclusionsExtra caution for DILI due to ALK ‐TKIs may be needed when recommending ALK‐TKIs for patients over 64 years of age, or with decreased renal function. CT images of the majority of patients with DILI by ALK‐TKIs show an OP pattern.Key points
Significant findings of the study: Extra caution is needed when recommending ALK ‐TKIs for patients over 64 years of age or those with decreased renal function. Computed tomography images of the majority of patients with DILI by ALK‐TKIs show an OP pattern.
What this study adds: The same or a different ALK‐TKI may be considered as a treatment option after the onset of DI LI, based on careful judgment.

Source: Thoracic Cancer - March 31, 2020 Category: Cancer & Oncology Authors: Ken Koshikawa, Jiro Terada, Mitsuhiro Abe, Shunichiro Iwasawa, Masashi Sakayori, Keiichiro Yoshioka, Yasutaka Hirasawa, Hajime Kasai, Yohei Kawasaki, Kenji Tsushima, Koichiro Tatsumi Tags: ORIGINAL ARTICLE Source Type: research