All that glitters is not prostate cancer: incidental finding of PSMA-avid meningioma.

We present a case of a 79 year old patient with a medical history of unilateral nerve-sparing radical prostatectomy due to a pT3aN0 (Gleason score 7) prostate carcinoma. Because of slightly elevated prostate specific antigen (PSA) level (0.35ng/dL), a fluorine-18-prostate specific membrane antigen (18F-PSMA)-1007 positron emission tomography/computed tomography (PET/CT) scan was performed, showing no signs of malignant recurrence. However, a moderately PSMA-avid nodular lesion was observed in the left occipital region with homogeneous contrast enhancement, suggestive for a meningioma, which was confirmed on magnetic resonance imaging (MRI). One year later, the lesion was resected due to a small but significant growth. Histology confirmed the diagnosis of a transitional type meningioma (WHO grade 1). PMID: 32222733 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

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CONCLUSION: The incidence of Prostate cancer was different between Baluch and Fars ethnicities in Iran. The lowest ASR of PCa was observed in Baluch ethnicity, however the possibility of underreporting due to less access in Baluch ethnicity cannot be ruled out. The Gleason distribution pattern was not concordant to the incidence distribution of Prostate cancer. PMID: 32406055 [PubMed - as supplied by publisher]
Source: Urology Journal - Category: Urology & Nephrology Authors: Tags: Urol J Source Type: research
Abstract Systemic therapy in uro-oncology is currently undergoing major changes. In the past, drug therapies only showed good treatment results in metastasized testicular tumors. New developments indicate that an improved understanding of tumor biology will lead to targeted treatment strategies for metastatic prostate, urothelial and renal cell carcinoma. In the following article, we summarize the practice-relevant innovations in systemic therapy in the guidelines on prostate cancer, transitional cell carcinoma of the bladder and renal cell carcinoma. PMID: 32300817 [PubMed - as supplied by publisher]
Source: Der Urologe. Ausg. A - Category: Urology & Nephrology Authors: Tags: Urologe A Source Type: research
We report a known case of severe achalasia that appeared on 68Ga–prostate-specific membrane antigen (PSMA) PET/CT. The patient was a known case of high-grade transitional cell carcinoma and suspicious diagnosis of prostate cancer referred for 68Ga-PSMA PET/CT. 68Ga-PSMA PET/CT showed linear increased activity in the esophageal wall as well as a distended esophagus.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Gere S. diZerega Intratumoral (IT) administration of submicron particle docetaxel (NanoDoce®, NanOlogy LLC, Fort Worth, TX, USA) and its efficacy against genitourinary-oncologic xenografts in rats and mice, xenograft-site docetaxel concentrations and immune-cell infiltration were studied. IT-NanoDoce®, IV-docetaxel and IT-vehicle were administered to clear cell renal carcinoma (786-O: rats), transitional cell bladder carcinoma (UM-UC-3: mice) and prostate carcinoma (PC-3: mice). Treatments were given every 7 days with 1, 2, or 3 doses administered. Animals were followed for tumor growth and clinical si...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionsThe addition of the botanical formula LCS101 to irradiated cancer cells results in an apparent additive effect, most likely through a ROS-mediated mechanism. These findings support the use of LCS101 by patients undergoing radiation therapy, for both its clinical as well as anti-cancer effects.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
We report a patient that had a prior radical prostatectomy and negative PSA levels for two years and subsequently developed bladder cancer requiring radical cystectomy with mixed lymph nodes on final pathology. The nodes were found to be positive for both metastatic urothelial cell carcinoma and metastatic prostatic adenocarcinoma based on immunohistochemical staining. Treatment for metastatic bladder cancer was pursued after radical cystectomy recovery.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: July 2018Source: European Urology, Volume 74, Issue 1Author(s): Wei Shen Tan, Andrew Feber, Rachael Sarpong, Pramit Khetrapal, Simon Rodney, Rumana Jalil, Hugh Mostafid, Joanne Cresswell, James Hicks, Abhay Rane, Alastair Henderson, Dawn Watson, Jacob Cherian, Norman Williams, Chris Brew-Graves, John D. Kelly, on behalf of DETECT I trial collaboratorsAbstractThere remains a lack of consensus among guideline relating to which patients require investigation for haematuria. We determined the incidence of urinary tract cancer in a prospective observational study of 3556 patients referred for investigation of ...
Source: European Urology - Category: Urology & Nephrology Source Type: research
We report a patient that had a prior radical prostatectomy and negative PSA levels for two years and subsequently developed bladder cancer requiring radical cystectomy with mixed lymph nodes on final pathology. The nodes were found to be positive for both metastatic urothelial cell carcinoma and metastatic prostatic adenocarcinoma based on immunohistochemical staining. Treatment for metastatic bladder cancer was pursued after radical cystectomy recovery.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: July 2018Source: European Urology, Volume 74, Issue 1Author(s): Wei Shen Tan, Andrew Feber, Rachael Sarpong, Pramit Khetrapal, Simon Rodney, Rumana Jalil, Hugh Mostafid, Joanne Cresswell, James Hicks, Abhay Rane, Alastair Henderson, Dawn Watson, Jacob Cherian, Norman Williams, Chris Brew-Graves, John D. Kelly, on behalf of DETECT I trial collaboratorsAbstractThere remains a lack of consensus among guideline relating to which patients require investigation for haematuria. We determined the incidence of urinary tract cancer in a prospective observational study of 3556 patients referred for investigation of ...
Source: European Urology - Category: Urology & Nephrology Source Type: research
In this study, we investigated the clinical value of diuretic delayed 18F-FDG PET/CT via taking small dose of diuretics orally in diagnosing urogential cancers. To our knowledge, it is the first report which has successfully used the oral intake of small dose of furosemide in diuretic 18F-FDG PET/CT. Methods: Forty-seven patients suspected of urogenital cancers from 2015 to 2017 were divided into small dosage group (26 males and 9 females, aged 33-82 years, 20mg furosemide) and routine dosage group (9 males and 3 females, aged 50-80 years, 40mg furosemide). All patients underwent whole body PET/CT scan (Discovery, GE Healt...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Prostate Posters Source Type: research
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