Resveratrol Significantly Attenuates Cell Mediated Immune Rejection against Xenogenic Bovine Pericardium

Resveratrol is a bioactive phenol shown to reduce T cell activation through inhibition of mTOR pathways. Recent studies show cell-mediated immune reactions cause structural valve deterioration (SVD) in xenograft valves. Thus, tissue-engineered heart valves (TEHV) with decellularized bovine pericardium have been developed to reduce the immune response. Our study examines whether resveratrol could further decrease the immune rejection against xenogenic bovine pericardium.

Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: J.J. Kang, S.J. Bozso, D. Boe, J. Nagendran, M.C. Moon, D.H. Freed, J. Nagendran Tags: (1197) Source Type: research