Echocardiographic Outcomes Following Left Ventricular Assist Device or Mitral Valve Repair in Severe Left Ventricular Dilatation with Mitral Regurgitation

Mitral regurgitation (MR) is a predictor of poor outcomes in patients with severe left ventricular dysfunction (LV) and options for repairing the valve have yielded conflicting results. We compared one-year echocardiographic and clinical outcomes of patients with grade 3-4MR and severe LV dilatation (end-diastolic dimension [LVEDD] above 65mm) undergoing either left ventricular assist device (LVAD) insertion alone or mitral valve repair (surgical minimally invasive repair or transcatheter edge-to-edge repair).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (822) Source Type: research

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Mitral regurgitation (MR) can complicate congenital heart disease, particularly when secondary to left ventricular dysfunction and mitral annular dilation. Significant MR is associated with substantial morbidity and mortality in patients with reduced LV systolic function, with recent studies demonstrating that percutaneous mitral valve repair can significantly reduce hospitalizations and all-cause mortality.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (578) Source Type: research
Pulmonary Thormboendarterectomy (PTE) has been shown to reduce tricuspid regurgitation. Tricuspid valve repair or replacement (TVR) in addition to the PTE has been used primarily in patients with more severe tricuspid regurgitation (TR), but the effects have not been evaluated.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1307) Source Type: research
Significant tricuspid regurgitation (TR) in patients undergoing durable left ventricular assist device (LVAD) implantation has been associated with increased incidence of right heart failure (RHF). There is great surgical practice variability related to moderate TR repair at the time of LVAD implantation. In this single-center study, we investigated whether moderate TR repair concurrent with LVAD implantation has impact on late RHF occurrence.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1125) Source Type: research
Significant aortic valve (AV) regurgitation is usually treated with AV replacement (AVR) or AV repair concomitant with left ventricular assist device (LVAD) surgery, as it can cause a closed-loop circulation, leading to a reduced left ventricular unloading and right ventricular (RV) function. However, data regarding survival after these AV procedures is limited. Therefore, the aim of this analysis was to evaluate the clinical outcome after concomitant AVR or AV repair in LVAD patients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (436) Source Type: research
Patients with significant aortic regurgitation at time of left ventricular assist device (LVAD) implantation, frequently need concomitant aortic valve (AV) replacement (AVR) or AV repair. The aim of this study was to investigate the risk for thromboembolic events (TE) in patients with concomitant continuous-flow LVAD and AV surgery.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (265) Source Type: research
This study shows that CA are released from periventricular and subpial regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis. Against Senolytics https://www.fightaging.org/archives/2019/11/against-senolytics/ There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionHB is a novel powder ‐based multiple component hemostatic agent that promotes focal or large area hemostasis. We have presented the techniques of use that are important to the successful application of HB to facilitate hemostasis.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: SURGICAL TECHNIQUE Source Type: research
In this study, we determine whether transient reintroduction of embryonic stem cell cycle miR-294 promotes cardiomyocyte cell cycle reentry enhancing cardiac repair after myocardial injury. A doxycycline-inducible AAV9-miR-294 vector was delivered to mice for activating miR-294 in myocytes for 14 days continuously after myocardial infarction. miR-294-treated mice significantly improved left ventricular functions together with decreased infarct size and apoptosis 8 weeks after MI. Myocyte cell cycle reentry increased in miR-294 hearts parallel to increased small myocyte number in the heart. Isolated adult myocytes from miR-...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, a significant (30%) increase in maximum lifespan of mice was found after nonablative transplantation of 100 million nucleated bone marrow (BM) cells from young donors, initiated at the age that is equivalent to 75 years for humans. Moreover, rejuvenation was accompanied by a high degree of BM chimerism for the nonablative approach. Six months after the transplantation, 28% of recipients' BM cells were of donor origin. The relatively high chimerism efficiency that we found is most likely due to the advanced age of our recipients having a depleted BM pool. In addition to the higher incorporation rates, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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