Combined Double-Lung Transplantation and Percutaneous Septal Defect Closure for End-Stage Atrial Septal Defect-Associated Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a rare but severe complication of unrepaired atrial septal defect (ASD) and carries a worse prognosis than posttricuspid shunt. In patients with ASD complicated by PAH and right ventricular failure, heart-lung transplantation (HLT) is currently viewed as the best option despite high postoperative mortality. However, the severe donor organ shortage results in high waiting-list mortality. Our objective here was to compare the safety and benefits of double-lung transplantation (DLT) followed by percutaneous ASD closure versus HLT for end-stage ASD-associated PAH.

Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: P. Gazengel, J. Le Pavec, O. Mercier, D. Fabre, S. Mussot, J. Petit, L. Savale, M. Humbert, S. Feuillet, E. Fadel, S. Hascoet Tags: (399) Source Type: research