Muscle Strength Is Associated With Muscle Mass in Patients With Esophageal Cancer Awaiting Surgery

Discussion: A tertiary referral center referred 125 individuals to physiotherapy who were eligible for the study; we finally included 93 individuals for statistical analysis. Multiple backward regression analysis showed that gender (95% confidence interval [CI], 2.05-33.82), weight (95% CI, 0.39-1.02), age (95% CI, −0.91 to −0.04), left handgrip strength (95% CI, 0.14-1.44), and inspiratory muscle strength (95% CI, 0.08-0.38) were all independently associated with muscle surface area at L3. All these variables together explained 66% of the variability (R2) in muscle surface area at L3 (P
Source: Journal of Geriatric Physical Therapy - Category: Physiotherapy Tags: Research Reports Source Type: research

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In order to limit radiotherapy (RT)-related side effects, effective toxicity prediction and assessment schemes are essential. In recent years, the growing interest toward artificial intelligence and machine learning (ML) within the science community has led to the implementation of innovative tools in RT. Several researchers have demonstrated the high performance of ML-based models in predicting toxicity, but the application of these approaches in clinics is still lagging, partly due to their low interpretability. Therefore, an overview of contemporary research is needed in order to familiarize practitioners with common me...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Condition:   Esophageal Cancer Interventions:   Drug: Lerotinib;   Drug: Irinotecan/Tegafur Sponsor:   Sunshine Lake Pharma Co., Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Oesophageal Cancer;   Esophageal Stent Stenosis Intervention:   Device: Multisegmented fully covered self-expandable metal stent Sponsors:   Radboud University;   Erasmus Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Esophageal Cancer Interventions:   Drug: Lerotinib;   Drug: Irinotecan/Tegafur Sponsor:   Sunshine Lake Pharma Co., Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Oesophageal Cancer;   Esophageal Stent Stenosis Intervention:   Device: Multisegmented fully covered self-expandable metal stent Sponsors:   Radboud University;   Erasmus Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Esophageal Cancer Interventions:   Drug: Lerotinib;   Drug: Irinotecan/Tegafur Sponsor:   Sunshine Lake Pharma Co., Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionMILE can be performed with low perioperative mortality, and favorable long-term overall and disease-free survival.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
ConclusionBlack patients with esophageal cancer are at higher risk of mortality compared to white patients. This increased risk may be influenced by decreased likelihood of receiving surgical intervention for resectable disease, in part because of between-hospital differences. Improving access to surgical care may improve disparities in esophageal cancer survival.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
ConclusionsLow HGS was a significant predictor of postoperative pneumonia after TLE for esophageal cancer.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
In conclusion, S-588410 induces a tumor immune response in esophageal cancer. Induction of CD8+ PD-1+ tumor-infiltrating lymphocytes and PD-L1 expression in the TME by vaccination suggests S-588410 in combination with anti-PD-(L)1 antibodies may offer a clinically useful therapy.Trial registration UMIN-CTR registration identifier: UMIN000023324.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
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