Spreading depolarization may represent a novel mechanism for delayed fluctuating neurological deficit after chronic subdural hematoma evacuation.

CONCLUSIONS: This is the first observation of SD occurring after cSDH evacuation. SD occurred at a rate of 15% and was associated with neurological deterioration. This may represent a novel mechanism for otherwise unexplained fluctuating neurological deficit after cSDH evacuation. This could provide a new therapeutic target, and SD-targeted therapies should be evaluated in prospective clinical trials. PMID: 32217801 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32217801?dopt=Abstract

Source: Journal of Neurosurgery - March 26, 2020 Category: Neurosurgery Authors: Mohammad LM, Abbas M, Shuttleworth CW, Ahmadian R, Bhat A, Hill DA, Carlson AP Tags: J Neurosurg Source Type: research