Acute cellular rejection in small-bowel transplantation impairs NCR+ innate lymphoid cell subpopulation 3/interleukin 22 axis.

CONCLUSION: The NCR+-ILC3/IL-22 axis is impaired during ACR contributing to a delay in or lack of a complete and efficient epithelial regeneration. Thus, our findings reveal that IL-22 analogues could potentially be used as a new complementary therapeutic approach, in conjunction with immunosuppressant drugs, in order to promote mucosal regeneration upon ACR.
PMID: 32209429 [PubMed - as supplied by publisher]

Source: Transplant Immunology - March 20, 2020 Category: Transplant Surgery Authors: Melisa PM, Virginia GP, Carolina R, Claudia F, Carlos L, Fabio N, Martín R, Gondolesi Gabriel E, Dominik M Tags: Transpl Immunol Source Type: research