Changes in PCSK9 and LDL cholesterol concentrations by everolimus treatment and their effects on polymorphisms in PCSK9 and mTORC1.

CONCLUSIONS: Administration of everolimus significantly elevated plasma PCSK9 concentrations, potentially causing everolimus-induced hyperlipidemia.
PMID: 32215854 [PubMed - as supplied by publisher]

Source: Pharmacological Reports - March 24, 2020 Category: Drugs & Pharmacology Authors: Sato S, Akamine Y, Kagaya H, Saito M, Inoue T, Numakura K, Habuchi T, Satoh S, Miura M Tags: Pharmacol Rep Source Type: research