GSE132218 Epigenetic footprint of hepatoblastoma defines a novel integrative molecular classification with clinical implications [CytoScanHD_Array]

Contributors : Juan Carrillo-Reixach ; Marina Simon-Coma ; Nicholas Akers ; Laura Royo ; Laura Torrens ; Magdalena Arnal ; N úria Villalmanzo ; Stefano Cairo ; Alberto Villanueva ; Roland Kappler ; Montserrat Domingo-Sàbat ; Marta Garrido ; Laura Guerra ; Constantino Sábado ; Gabriela Guillén ; Mar Mallo ; David Piñeyro ; María Vázquez-Vitalí ; Olga Kuchuk ; María Elena Mateos ; Gema Ramírez ; Man uel López Santamaría ; Yasmina Mozo ; Aroa Soriano ; Michael Grotzer ; Sophie Branchereau ; Nagore García de Andoin ; Blanca López-Ibor ; Ricardo López-Almaraz ; José Antonio Salinas ; Bárbara Torres ; Francisco Hernández ; José Javier Uriz ; Monique Fabre ; Julià Blanco ; Cl audia Paris ; Viera Bajčiová ; Geneviève Laureys ; Elena Masnou ; Cristina Belendez ; Catherine Guettier ; Lauro Sumoy ; Ramón Planas ; Mireia Jorda ; Lara Nonell ; Piotr Czauderna ; Bruce Morland ; Margarita Sala ; Daniela SiaSeries Type : Genome variation profiling by SNP arrayOrganism : Homo sapiensHepatoblastoma (HB) is the predominant pediatric liver cancer with limited therapeutic options for patients with aggressive tumors. Nevertheless, it is a rare disease. Here, we performed a high-throughput molecular study of 32 patients with HB and major findings were validated in additional 80 cases. We unveiled an epigenetic footprint including downregulation of RNA-editing, hyperediting of the tumor suppressor BLCAP,14q32 DLK1-DIO3 locus ov...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome variation profiling by SNP array Homo sapiens Source Type: research