NOTCH3 T6746C and TP53 P72R Polymorphisms Are Associated with the Susceptibility to Diffuse Cutaneous Systemic Sclerosis.

Conclusion: The CT + CC genotypes of NOTCH3 gene and PR + RR genotypes of the TP53 gene increased the risk of dcSSc development. Moreover, genotypes of CT + CC were associated with the active form of SSc suggesting the role of the NOTCH pathway in the pathogenesis of this disease.NOTCH3 and TP53 genes and serum anti-TP53 antibodies with the susceptibility, clinical subset of systemic sclerosis (SSc), and clinical profile of SSc patient, particularly with lung involvement and disease activity.
PMID: 32185220 [PubMed - in process]

Source: Biomed Res - March 20, 2020 Category: Research Authors: Zmorzyński S, Wojcierowska-Litwin M, Kowal M, Michalska-Jakubus M, Styk W, Filip AA, Walecka I, Krasowska D Tags: Biomed Res Int Source Type: research