Assessment of a high-avidity IgG ANAs for the diagnosis and activity prediction of systemic lupus erythematosus

ConclusionsFirst, we demonstrated that HA IgG ANA was a reliable diagnostic tool in SLE patients. Furthermore, HA IgG ANA was supposed to be more appropriate for identifying the activity of SLE compared with HA dsDNA IgG. In summary, HA IgG ANA may be a new biomarker for diagnosing SLE and identifying SLE activity.Key Points• We first introduced the concept of a “high-avidity IgG ANA (HA IgG ANA)” that could distinguish between the early stage of SLE and SLE that had been active for some time.• The relative avidity indexes (RAIs) of HA IgG ANA and HA dsDNAIgG were presented and applied here to evaluate the avidities of antibodies involved in SLE.• In our study, we confirmed the value of HA IgG ANA in diagnosing SLE. In addition, HA IgG ANA was more appropriate for identifying the activity of SLE than was HA dsDNA IgG.• In conclusion, HA IgG ANA could be a potential biomarker for the assessment of the prognosis of SLE activity.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research