Use of Perampanel and a Ketogenic Diet in Nonketotic Hyperglycinemia: A Case Report

Conclusion Perampanel reduced fast excitatory neuronal activity, which was induced by an α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, followed by prolonged electrical depolarizations due to an N-methyl-D-aspartate receptor. Furthermore, the ketogenic diet may have modulated the excessive neurotoxic cascade through the N-methyl-D-aspartate receptor. Perampanel and ketogenic diet were effective for seizure control in our patient. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Neuropediatrics - March 15, 2020 Category: Neurology Authors: Daida, Atsuro Hamano, Shin-ichiro Ikemoto, Satoru Hirata, Yuko Matsuura, Ryuki Koichihara, Reiko Oba, Daiju Ohashi, Hirofumi Tags: Short Communication Source Type: research