Characterisation of the heterozygous glucokinase knockout mouse as a translational disease model for glucose control in type 2 diabetes

Conclusions and implicationsStandard glucose lowering therapeutic agents demonstrated significant acute glucose lowering in male gkwt/del mice at exposures corresponding to therapeutic free drug levels in man, suggesting the potential of these mice as a translatable model of human T2D. Novel GKAs also show glucose lowering efficacy in this mouse model.

Source: British Journal of Pharmacology - November 6, 2013 Category: Drugs & Pharmacology Authors: D J Baker, A M Atkinson, G P Wilkinson, G J Coope, A D Charles, B Leighton Tags: Research Paper Source Type: research