Protective effects of rimeporide on left ventricular function in golden retriever muscular dystrophy dogs

Alterations in intracellular Na+ and Ca2+ have been observed in patients with Duchenne muscular dystrophy (DMD) and in animal models of DMD, and inhibition of Na+-H+ exchanger 1 (NHE1) by rimeporide has previously demonstrated cardioprotective effects in animal models of myocardial ischemia and heart failure. Since heart failure is becoming a predominant cause of death in DMD patients, this study aimed to demonstrate a cardioprotective effect of chronic administration of rimeporide in a canine model of DMD.

Source: International Journal of Cardiology - March 11, 2020 Category: Cardiology Authors: Bijan Ghaleh, In ès Barthélemy, Jérôme Wojcik, Lucien Sambin, Alain Bizé, Luc Hittinger, Thien Duc Tran, Florence Porte Thomé, Stéphane Blot, Jin Bo Su Source Type: research