Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor- β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro.

CONCLUSIONS: The present study demonstrated that miR-34a-over-expressing MSC-MVs inhibit EMT induced by pro-fibrotic TGF-β1 in renal tubular epithelial cells, possibly through inhibition of the Jagged-1/Notch-1 pathway. Genetic modification of MSC-MVs with an anti-fibrotic molecule may represent a novel strategy for the treatment of renal injuries. PMID: 32149762 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32149762?dopt=Abstract

Source: Chinese Medical Journal - March 5, 2020 Category: General Medicine Authors: He J, Jiang YL, Wang Y, Tian XJ, Sun SR Tags: Chin Med J (Engl) Source Type: research