MiR-4458/human antigen R (HuR) modulates PBX3 mRNA stability in melanoma tumorigenesis

In this study, it revealed the stabilization of PBX3 mRNA by HuR, thereby boosting PBX3 expression. Lastly, we concluded that miR-4458 and HuR modulated the expression of PBX3 in a competitive manner in melanoma tumorigenesis, which might yield a novel insight into the molecular pathogenesis of melanoma.

Source: Archives of Dermatological Research - March 8, 2020 Category: Dermatology Source Type: research