Combination of inflammatory score/liver function and AFP improves the diagnostic accuracy of HBV ‐related hepatocellular carcinoma

ConclusionsElderliness, male sex, elevated ALT, AST, NLR, AFP, cirrhosis, HBeAg+, and no ‐antiviral treatment were independent risk factors for HBV‐HCC. AASLD standard of ALT cut‐off value may not be suitable for the Chinese population. Regular monitoring of HCC among HBeAg‐ patients with abnormal AFP may improve the management of HBV ‐HCC. The diagnostic performance of AFP combined with ALT, AST, and NLR for HBV‐HCC was superior to single biomarker or any other combinations among these patients, and its diagnostic equation can be used as useful tool for differentiation of HBV‐HCC from CHB.

Source: Cancer Medicine - March 10, 2020 Category: Cancer & Oncology Authors: Yezhou Ding, Kehui Liu, Yumin Xu, Qingqing Zhao, Shike Lou, Xiaogang Xiang, Lei Yan, Zhujun Cao, Qing Xie, Chuanwu Zhu, Shisan Bao, Hui Wang Tags: ORIGINAL RESEARCH Source Type: research