Drug which blocks intestinal absorption of cholesterol
Drug which blocks intestinal absorption of cholesterol:
a) Atorvastatin
b) Gemfibrozil
c) Ezetimibe
d) Rosuvastatin
Correct answer: c) Ezetimibe
Ezetimibe acts by selectively blocking the uptake of cholesterol and other sterols by intestinal epithelial cells. The action is on Niemann-Pick C1-like 1 (NPC1L1) cholesterol uptake receptors.
Interestingly, it has been recently shown that NPC1L1 expression is necessary for HCV (hepatitis C virus) infection. Ezetimibe can block the entry of HCV into the cell, in experimental situations. Clinical effect on this aspect has to be further studied [Sainz B Jr et al. Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor. Nat Med. 2012 Jan 8;18(2):281-5]
Source: Cardiophile MD - Category: Cardiology Authors: Prof. Dr. Johnson Francis MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Niemann-Pick C1-like 1 receptor NPC1L1 Source Type: blogs
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