Analysis of Risk Factors for Anorectal Stenosis of Perianal Fistulizing Crohn's Disease.

CONCLUSIONS Higher CDAI and older age at diagnosis appear to confer higher risk of anorectal stenosis associated with PFCD. PMID: 32109226 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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(University of California - Riverside) A protein-coding gene associated with autoimmune diseases such as Crohn's disease and ulcerative colitis, collectively referred to as inflammatory bowel disease, or IBD, will be the focus of new research in the School of Medicine at the University of California, Riverside. The work is made possible by a National Institutes of Health grant exceeding $2.5 million.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
We have recently observed a case of acute kidney Injury (AKI) in a patient with Crohn's disease (CD) receiving isoniazid (INH) prophylaxis for latent tuberculosis infection (LTBI). While the most common INH-related adverse events are well-known and include asymptomatic elevation of serum liver enzyme concentrations, peripheral neuropathy and hepatotoxicity, INH-induced AKI is a very rare event that has been occasionally reported in the literature particularly in pediatric patients [1-3].
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Correspondence Source Type: research
In this study, we further explored the effect of sucralose on tumorigenesis and the possible mechanism involved using the AOM/DSS mouse model. First, 1.5 mg/ml sucralose was included in the drinking water for 6 weeks to reach a relatively stable phase of impact on gut microbiota. Then, 10 mg/kg AOM was administered through intraperitoneal injection. Seven days later, 2.5% DSS was put in the drinking water for 5 days, followed by 2 weeks without DSS. The 5 days of DSS was then repeated, and the mice were sacrificed 6 weeks after AOM injection. The results showed that sucralose caused significant increases in the number and ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurposeTo determine the incidence and clinical relevance of extra-intestinal incidental findings (IF) in a cohort of patients with proven or suspected Crohn disease (CD) examined with magnetic resonance enterography (MR-E) in a single University Centre.MethodsBetween January 2018 and June 2019, 182 patients with proven or suspected CD with a planned first MR-E examination, were retrospectively included in this study. Incidental findings were considered as any abnormality identified in the absence of previous clinically suspected or known disease. IF were categorized as unremarkable, benign or potentially relevant f...
Source: La Radiologia Medica - Category: Radiology Source Type: research
AbstractObjectivesPrimary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure.Secondary objectives:To evaluate the efficacy of melatonin as a prophylactic treatment on prevention of asymptomatic SARS-CoV-2 infection.To evaluate the efficacy of melatonin to prevent the development of severe COVID-19 in the participants enrolled in this study who develop SARS-CoV-2 infection along the trial.To evaluate the duration of COVID-19 symptoms in participants receiving melatonin before the infection...
Source: Trials - Category: Research Source Type: clinical trials
Add “improving” before “detection”? PET/MR is beneficial particularly in pediatric patients who undergo recurrent imaging, such as those with cancer or chronic inflammatory disease. PET/MR has advantages compared with PET/computed tomography, including decreased radiation exposure and superior c haracterization of soft tissue. Ongoing challenges include reducing examination duration and costs and detection of pulmonary lesions. Accepted clinical applications of PET/MR in pediatric patients are evaluation of epileptic foci and diagnosis, staging, and follow-up of solid tumors. PET/MR also ma y have a...
Source: PET Clinics - Category: Radiology Authors: Source Type: research
Conclusion: Patients undergoing emergency surgery for CD are at increased risk of exposure to ionizing radiations due to high perioperative use of CT scan.
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - Category: Surgery Tags: Original Articles Source Type: research
Contributors : Fatemeh Adiliaghdam ; Sreehaas Digumarthi ; Lai P Wong ; Ruslan Sadreyev ; Kate L JeffreySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPeripheral blood-derived macrophages were stimulated with viral-like particles isolated from colonic resections from patients with Crohn's disease (CD), ulcerative colitis (UC), or non-IBD controls diagnoses. RNAseq was performed to unbiasedly assess the transcriptional responses to these stimuli and revealed highly divergent macrophage transcriptional programs in response to non-IBD compared to IBD VLP.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Publication date: Available online 30 May 2020Source: European Journal of RadiologyAuthor(s): L. Tkalčić, Kaštelan Z. Matana, T. Grubešić, Sinčić B. Mijandrušić, S. Milić, D. Miletić
Source: European Journal of Radiology - Category: Radiology Source Type: research
Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Letter to the Editor Source Type: research
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