Demeclocycline Attenuates Hyponatremia by Reducing Aquaporin-2 Expression in the Renal Inner Medulla.

In conclusion, our in vitro and in vivo data indicate that demeclocycline mainly attenuates hyponatremia in SIADH by reducing adenylate cyclase 5/6 expression, and consequently cAMP generation, AQP2 gene transcription and AQP2 abundance in the renal inner medulla, coinciding with a reduced vasopressin-escape response in the other collecting duct segments.
PMID: 24154696 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - October 23, 2013 Category: Urology & Nephrology Authors: Kortenoeven ML, Sinke AP, Hadrup N, Trimpert C, Wetzels JF, Fenton RA, Deen PM Tags: Am J Physiol Renal Physiol Source Type: research