FTY720 Ameliorates Acute Ischemic Stroke in Mice by Reducing Thrombo-Inflammation but Not by Direct Neuroprotection [Basic Sciences]

Conclusions—
Induction of lymphocytopenia and concomitant reduction of microvascular thrombosis are key modes of FTY720 action in stroke. In contrast, our findings in Rag1–/– mice and cultured neurons argue against direct neuroprotective effects of FTY720.

Source: Stroke - October 21, 2013 Category: Neurology Authors: Kraft, P., Gob, E., Schuhmann, M. K., Gobel, K., Deppermann, C., Thielmann, I., Herrmann, A. M., Lorenz, K., Brede, M., Stoll, G., Meuth, S. G., Nieswandt, B., Pfeilschifter, W., Kleinschnitz, C. Tags: Animal models of human disease, Ischemic biology - basic studies, Acute Cerebral Infarction, Pathology of Stroke, Anticoagulants Basic Sciences Source Type: research