Deficient eNOS Phosphorylation Is a Mechanism for Diabetic Vascular Dysfunction Contributing to Increased Stroke Size [Basic Sciences]

Conclusions—
Diminished eNOS phosphorylation is a mechanism of vascular dysfunction in db/db mice. We show here that modulation of the eNOS S1176 phosphorylation site in db/db mice is associated with improved vascular reactivity and improved outcome to stroke after middle cerebral artery occlusion.

Source: Stroke - October 21, 2013 Category: Neurology Authors: Li, Q., Atochin, D., Kashiwagi, S., Earle, J., Wang, A., Mandeville, E., Hayakawa, K., d'Uscio, L. V., Lo, E. H., Katusic, Z., Sessa, W., Huang, P. L. Tags: Animal models of human disease, Genetically altered mice, Type 2 diabetes, Acute Cerebral Infarction, Endothelium/vascular type/nitric oxide Basic Sciences Source Type: research