Ulcerative colitis: bacteria findings raise hopes for new treatment

Sufferers found to have low levels of gut microbes that convert bile acids into other substancesHopes of developing a new treatment for ulcerative colitis have been raised by research suggesting the condition may be linked to low levels of certain bacteria in the gut.Ulcerative colitis is a long-term condition in whichthe colon becomes inflamed. Accordingto the NHS, it is thought to be an autoimmune disease and affects one in every 420 people in the UK. Sufferers need to empty their bowels frequently, develop ulcers in their colon and have recurring bouts of diarrhoea with blood and pus in the faeces.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Digestive disorders Science Health & wellbeing Life and style Society Source Type: news

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In this study, five machine learning algorithms and twelve types of molecular fingerprints were employed to generate QSAR discriminant models for mitochondrial toxicity. A threshold moving method was adopted to resolve the imbalance issue in the training data. Consensus of the models by an averaging probability strategy improved prediction performance. The best model has correct classification rates of 81.8% and 88.3% in ten-fold cross validation and external validation, respectively. Substructures such as phenol, carboxylic acid, nitro and arylchloride were found informative through analysis of information gain and freque...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Publication date: Available online 29 May 2020Source: Blood Cells, Molecules, and DiseasesAuthor(s): Gardellini Angelo, Francesca Guidotti, Zancanella Michelle, Saccà Vittoria, Maddalena Feltri, Luciana Ambrosiani, Turrini Mauro
Source: Blood Cells, Molecules, and Diseases - Category: Hematology Source Type: research
AbstractCrohn ’s disease (CD) is a type of inflammatory bowel disease (IBD) and affects diverse segments of the entire gastrointestinal tract. Although the underlying causes of CD are not completely known, it is believed that disruption of the intestinal barrier and cell polarity may contribute to pathogenesis. The formation of the intestinal epithelial barrier, which is mainly regulated by cytoskeletal modulations, and apico-basal cell polarity are two major and mutually dependent features of the intestinal epithelial layer. As this layer serves as an important barrier between the external environment an d the inter...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Authors: Desilets A, Soulières D Abstract INTRODUCTION: Programmed death 1 (PD-1) blockade has changed the therapeutic landscape of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) with convincing overall response rates and overall survival benefits when compared to chemotherapy alone. The toxicity profile of pembrolizumab appears to be similar to that of other PD-1 or PD-L1 inhibitors, with frequent diarrhoea, hypothyroidism or cutaneous rash cases, and rare cases of grade 3 to 5 pneumonitis.Areas covered: In this article, the pharmacokinetics and mechanism of action of pembrolizuma...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Condition:   Ulcerative Colitis Intervention:   Diagnostic Test: Red Density Sponsors:   Universitaire Ziekenhuizen Leuven;   Sapporo Medical University;   Imelda GI Clinical Research Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
NEW YORK (Reuters Health)—Patients treated with biologic therapy for rheumatoid arthritis, inflammatory bowel disease and psoriasis don’t appear to be at increased risk of melanoma, according to the results of a systematic review and meta-analysis. However, because the study found trends toward increased melanoma rates with long-term therapy, “a clinically meaningful increase in risk cannot... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Drug Updates Biologics melanoma skin skin cancer Source Type: research
Condition:   Ulcerative Colitis Intervention:   Diagnostic Test: Red Density Sponsors:   Universitaire Ziekenhuizen Leuven;   Sapporo Medical University;   Imelda GI Clinical Research Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Tarn JR, Lendrem DW, Isaacs JD Abstract INTRODUCTION: Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease. Early referral and treatment are key to the effective management of the disease. This makes imperative the identification of biomarkers and of pathobiological endotypes. AREAS COVERED: This review describes recent efforts to integrate large-scale datasets for the identification of disease endotypes for precision medicine in early, seropositive RA. We conducted a search for systems and multi-omics papers in early RA patients through to 1 January 2020. We reviewed investigations of m...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
In this study, we firstly investigated the expression of OX40, 4-1BB, GITR, ICOS, CTLA-4, LAG-3, and TIM-3 on CD8+ T cells from untreated patients with AA and healthy individuals (HIs) by flow cytometry. Moreover, we further analyzed the phenotype and functional characteristics of CD8+GITR+ T cells to more fully assess the T cell activation dysfunction in AA. We for the first time demonstrated significantly decreased percentage of CD8+GITR+ T cells in AA, and CD8+GITR+CTLA-4+ T cells were significantly higher in patients with AA compared with HIs. Conversely, the percentage of CD8+GITR+granzyme B+ and CD8+GITR+perforin+ T ...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Conclusions: Methylation analysis, namely of MSH6, may contribute to the classification of dysplastic lesions in IBD- to be further tested in prospective studies. PMID: 32456486 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
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