Weight evolution after implantation of left ventricular assist device: Do we need to interfere?
CONCLUSION: Although the initial 6 months evolve beneficial, all patients gain weight in the second year and do not further improve their exercise capacity. PMID: 32089042 [PubMed - as supplied by publisher]
In the era of increased left ventricular support device (LVAD) implantation, limited data is available on outcomes in the obese population, with most available data describing elevated BMI with a cutoff of>30 kg/m2. Forest et al examined the ISHLT Mechanically Assisted Circulatory Support (IMACS) registry and found no impact in 2-year mortality in those with higher BMIs, but an increase in all adverse events describing BMI> 40 kg/m2 group. We seek to provide our experience with this population.
Review our single center experience of morbidly obese patients with end-stage heart failure (ESHF) that underwent left ventricular assist device (LVAD) implantation.
Risk factors such as diabetes mellitus (DM) have been associated with increased risk of mortality in patients with heart failure (HF). Obesity in diabetic patients worsens outcomes. However, there appears to be an obesity paradox in which stable HF patients with higher body mass index (BMI) have better survival. We sought to evaluate the association of DM and BMI with mortality in patients with end stage HF on palliative inotropic therapy.
Discussion of the Evolutionary Genetics of Aging Thymic Involution Contributes to Immunosenescence and Inflammaging The Potential for Exosome Therapies to Treat Sarcopenia Correlations of Mitochondrial DNA Copy Number and Epigenetic Age Measures Evidence for PASK Deficiency to Reduce the Impact of Aging in Mice The Aging Retina, a Mirror of the Aging Brain Evidence for Loss of Capillary Density to be Important in Heart Disease Aspects of Immune System Aging Proceed More Rapidly in Men Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation Transplantation of Senescent Cells is an ...
Abstract BACKGROUND: Because of the growing prevalence of terminal heart failure on the one hand and organ shortage on the other hand, an optimal care of heart transplant recipients based on the knowledge of potential risk factors not only early, but also in a long-term course after heart transplantation is of great importance. Therefore, the aim of the present study was to identify predisposing factors for late mortality in this patient collective. METHODS: Data from long-term heart transplant patients collected during follow-up visits in the current center were retrospectively analyzed. Clinical, laboratory...
By 2030, 1 of 2 adults in the United States will be obese, defined as a body mass index (BMI) ≥ 30 kg/m2, and nearly 1 in 4 will suffer from extreme obesity, a BMI ≥ 35 kg/m2.1 Obesity can impair left ventricular structure and contractile function and is an independent risk factor for the development of heart failure (HF). Although there is a modest protective benefit to being overweight once HF is established—the famous “obesity paradox”—an increasing number of obese patients with advanced systolic HF are undergoing evaluation for heart transplantation and durable mechanical circulatory support (MCS).
By 2030, 1 in 2 adults in the United States will be obese, defined as a body mass index (BMI) ≥30kg/m2, and nearly 1 in 4 will suffer from extreme obesity with a BMI ≥35 kg/m2.1 Obesity can impair left ventricular structure and contractile function and is an independent risk factor for the development of heart failure (HF). Although there is a modest protective benefit to being overweigh t once HF is established—the famous “obesity paradox—an increasing number of obese patients with advanced systolic HF are undergoing evaluation for heart transplantation and durable mechanical circulatory support (MCS).
This article explores the viral pathogens commonly found to cause myocardial inflammation, their sequelae, and treatment. PMID: 32000238 [PubMed - in process]
This article explores the viral pathogens commonly found to cause myocardial inflammation, their sequelae, and treatment.
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...