Novalung FDA Cleared to Provide Long-Term Lung Failure Treatment

Critically ill patients with acute respiratory or cardiopulmonary failure who are on long-term mechanical ventilation too often suffer a variety of side effects. These can include ventilator associated lung injury, pneumonia, and diaphragm dysfunctio...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Cardiac Surgery Cardiology Critical Care Pediatrics Source Type: blogs

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ConclusionClearly, not all developing world contexts are ready to attempt thoracoscopic repair but we outline suggestions for assessing the existing capabilities and a stepwise gradual implementation of advanced thoracoscopy when appropriate.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
With the rise of COVID-19 cases throughout the United States, one of the biggest concerns is the potential shortage of ventilators for patients who have severe viral pneumonia. A team at the University of Minnesota has designed a mechanical ventilato...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Cardiology Critical Care Materials Medicine News Public Health Source Type: blogs
Conclusion: Anesthetic management with GA or CS during MT had no differential impact on the functional outcomes and mortality at discharge or 3 months after stroke in AIS patients, but CS led to more stable hemodynamics and lower incidence of pneumonia.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Authors: Shionoya Y, Kamiga H, Tsujimoto G, Nakamura E, Nakamura K, Sunada K Abstract Systemic sclerosis (SSc) is an autoimmune disease that can cause fibrosis in vital organs, often resulting in damage to the skin, blood vessels, gastrointestinal system, lungs, heart, and/or kidneys. Patients with SSc are also likely to develop microstomia, which can render dental treatment difficult and painful, thereby necessitating advanced anesthetic management. This is a case report of a 61-year-old woman with a history of SSc with microstomia, interstitial pneumonia, and gastroesophageal reflux disease in whom intravenous mo...
Source: Anesthesia Progress - Category: Anesthesiology Tags: Anesth Prog Source Type: research
Background High-density lipoproteins exert pleiotropic effects including antiinflammatory, antiapoptotic, and lipopolysaccharide-neutralizing properties. The authors assessed the effects of reconstituted high-density lipoproteins (CSL-111) intravenous injection in different models of sepsis.Methods Ten-week-old C57BL/6 mice were subjected to sepsis by cecal ligation and puncture or intraperitoneal injection of Escherichia coli or Pseudomonas aeruginosa pneumonia. CSL-111 or saline solution was administrated 2 h after the sepsis. Primary outcome was survival. Secondary outcomes were plasma cell-free DNA and cytokine concent...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Conclusions Systemic C5a is elevated in pneumonia patients. Neutralizing C5a protected against lung and liver injury in pneumococcal pneumonia in mice. Early neutralization of C5a might be a promising adjunctive treatment strategy to improve outcome in community-acquired pneumonia.Editor ’s PerspectiveWhat We Already Know about This TopicPneumonia, sepsis, and immune dysregulation cause morbidity and mortalityC5a is a component of the complement system and a proinflammatory mediator that modulates the innate immune response in critical illnessDisruption of the C5a receptor axis with antibodies or antagonists was prev...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Conclusions Low-dose intrathecal morphine, in conjunction with multimodal analgesia, was not reliably associated with postoperative pulmonary complications in patients with obstructive sleep apnea undergoing joint arthroplasty.Editor ’s PerspectiveWhat We Already Know about This TopicIntrathecal morphine is commonly and effectively used for analgesia after joint arthroplasty, but has been associated with postoperative pulmonary complications such as delayed respiratory depressionPatients with obstructive sleep apnea may be at higher risk of these complications, especially if intrathecal morphine is used for analgesia...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
In the past decade, the critical care community witnessed an increased interest and use of extracorporeal life support (ECLS) for adult patients with respiratory and heart failure. Although extracorporeal membrane oxygenation has been developed for clinical applications since the early 1970s,1 it has not been accepted widely in adult critical care owing to technical difficulties and the absence of strong evidence. In 2009, ECLS emerged as lifesaving technology for patients with severe acute respiratory distress syndrome secondary to H1N1 pneumonia.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
Conclusion CAS in maintenance hemodialysis patients may be feasible and effective for the prevention of stroke with proper case selection, appropriate technique and strict perioperative management. The most common causes of death during the follow-up of maintenance hemodialysis patients were diseases other than stroke. PMID: 32062623 [PubMed - in process]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusions: MPLA was well tolerated in burned sheep and attenuated development of acute lung injury, lactatemia, cytokinemia, vascular leak, and hemodynamic changes caused by Pseudomonas aeruginosa pneumonia.
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
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