Regular (ICSI) versus ultra-high magnification (IMSI) sperm selection for assisted reproduction.
CONCLUSIONS: The current evidence from randomised controlled trials does not support or refute the clinical use of intracytoplasmic sperm injection (intracytoplasmic morphologically selected sperm injection (IMSI). We are very uncertain of the chances of having a live birth and of the risk of having a miscarriage. We found very low-quality evidence that IMSI may increase chances of a clinical pregnancy, which means that we are still very uncertain about any real difference. We did not find any trials reporting on the risk of congenital abnormalities. Well-designed and sufficiently powered trials are still required. PMID: 32083321 [PubMed - in process]
Conditions: Infertility; Recurrent Implantation Failure; Recurrent Miscarriage Intervention: Sponsor: Peking University Third Hospital Not yet recruiting
CONCLUSIONS: While avoiding unnecessary embryo transfers and miscarriages are important goals, patients and doctors need to be aware of the high cost implications of applying PGT-A using aCGH on polar bodies. FUNDING: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The ESTEEM study was funded by the European Society for Human Reproduction and Embryology. Illumina provided microarrays and other consumables necessary for aCGH testing of polar bodies. PMID: 31930663 [PubMed - as supplied by publisher]
ConclusionsAOA was able to “rescue” the poor reproductive outcomes in certain types of infertile couples with history of failure pregnancy.
CONCLUSION: MCDA twins after IVF/ICSI have lower overall survival rates and higher rates of second-trimester miscarriage compared to spontaneously conceived MCDA twins. This article is protected by copyright. All rights reserved. PMID: 31909558 [PubMed - as supplied by publisher]
CONCLUSIONS: UtA-PI and proportion of SGA are lower in pregnancies after frozen as compared to fresh blastocyst transfer. This article is protected by copyright. All rights reserved. PMID: 31909549 [PubMed - as supplied by publisher]
ConclusionsChromosomal aberrations and aneuploidy manifested specific characteristics that differed between TEs and SA-CVBs, which indicates that distinct chromosomal abnormalities can affect certain developmental stages of embryos. Further analysis is needed to explore the chromosomal mechanisms affecting embryo development and implantation. Such information will help clinical assessments in prenatal diagnosis and reduce the incidence of genetically abnormal fetuses.
Conclusionshp-HMG and rFSH did not lead to significantly different treatment outcomes in patients with poor ovarian response undergoing in vitro fertilization/intracytoplasmic sperm injection with a gonadotropin-releasing hormone antagonist protocol, although significantly higher serum insulin-like growth factor-1 level and insignificantly lower serum insulin-like growth factor binding protein-1 level on the day of oocyte retrieval associated with hp-HMG might suggest a beneficial endocrine environment. (Curr Ther Res Clin Exp. 2020; 81:XXX–XXX)
Conclusions: Women undergoing IVF/ICSI with a previous CS have a lower live birth rate and a higher miscarriage rate than those with a previous VD.
Authors: Yang DN, Wu JH, Geng L, Cao LJ, Zhang QJ, Luo JQ, Kallen A, Hou ZH, Qian WP, Shi Y, Xia X Abstract This meta-analysis was intended to evaluate the effects of intrauterine perfusion of peripheral blood mononuclear cells (PBMC) on the pregnancy outcomes including clinical pregnancy rates, embryo implantation rates, live birth rates and miscarriage rates of infertile women who were undergoing in vitro fertilisation (IVF) treatment. By searching Pubmed, Embase database, five articles meeting the inclusion criteria were included, and 1173 women were enrolled (intrauterine PBMC group: n = 514; NO-P...
Conclusionshp-HMG and rFSH did not lead to significantly different treatment outcomes in POR patients undergoing IVF/ISCI with a GnRH antagonist protocol, although significantly higher serum IGF-1 level and insignificantly lower serum IGFBP-1 level on the day of oocyte retrieval associated with hp-HMG might suggest a beneficial endocrine environment.