Cancers, Vol. 12, Pages 515: New Deployable Expandable Electrodes in the Electroporation Treatment in a Pig Model: A Feasibility and Usability Preliminary Study

Cancers, Vol. 12, Pages 515: New Deployable Expandable Electrodes in the Electroporation Treatment in a Pig Model: A Feasibility and Usability Preliminary Study Cancers doi: 10.3390/cancers12020515 Authors: Francesco Izzo Franco Ionna Vincenza Granata Vittorio Albino Renato Patrone Francesco Longo Agostino Guida Paolo Delrio Daniela Rega Dario Scala Roberto Pezzuto Roberta Fusco Elio Di Bernardo Valeria D’Alessio Roberto Grassi Deyanira Contartese Raffaele Palaia The aim of the study is to evaluate the usability aspects of new deployable, expandable, electrode prototypes, in terms of suitability solutions for laparoscopic applications on the liver, endoscopic trans-oral and trans-anal procedures, electroporation segmentation in several steps, mechanical functionality (flexibility, penetrability), visibility of the electrode under instrumental guidance, compatibility of the electrode with laparoscopic/endoscopic accesses, surgical instruments, and procedural room and safety compatibility. The electroporation was performed on an animal model (Sus Scrofa Large White 60 kg) both in laparoscopy and endoscopy, under ultrasound guidance, and in open surgery. Electrodes without divergence, with needles coming out straight, parallel to each other, and electrodes with peripheral needles (four needles), diverging from the electrode shaft axis (electrode with non-zero divergence) have been tested. To cause an evaluable necrosis effect, the number...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research