107. Ultrasound investigations in sickle cell anemia. Initial assessment and follow up

This study was proposed to compare two different equipment: TCD (trans-cranial doppler) and TCCS (transcranial color-coded sonography) with or without using the angular correction, in a group of patients with the sickle cell anemia in order to identify the most suitable technique for the sampling of blood velocity (TAMM). 35 pediatric patients without previus history of neurological disease or transfusion were enrolled. Arteries examined were the middle cerebral artery, the anterior cerebral artery, the posterior cerebral and the basilar arteries. TAMM values greater than 200cm/s identify patients at high risk of stroke who are candidates for transfusion therapy. Our study demonstrated that there was a good correlation between TCCS and TCD. In addition, we found that if applied the angular correction to the TCCS increases the number of false-positive doppler examination. According to our study, we recommend to perform an initial assessment of the intracranial circulation with a method that allows to have morphological information, without the application of the angular correction. Indeed, the study of sickle cell anemia is complicated by the peculiar small diameter of the arteries and numerous variant of the circle of Willis.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Tags: Society Proceedings Source Type: research