Clinical Significance of Hypophosphatasemia in Children

In conclusion, reflected persistent hypophosphatasemia frequency was 1/1552 (0.06%) in this large pediatric cohort and,ALPL gene mutations were detected in 13.5% (5/37) of the studied cases. Although biochemical hypophosphatasemia is not uncommon, clinically significant HPP is rare.

http://link.springer.com/10.1007/s00223-020-00677-4

Source: Calcified Tissue International - February 21, 2020 Category: Orthopaedics Source Type: research