Frailty – A promising concept to evaluate disease vulnerability

We describe how high levels of frailty in such disorders predict worse outcomes and play a direct role in disease progression and in prognostic prediction. Overall, the potential for frailty to predict adverse health outcomes among young people as well as in non-age-related diseases is an evolving topic. Understanding how frailty contributes to poor health and how it can be modified to prevent or delay disease progression will ultimately enhance quality of life in affected individuals.
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research

Related Links:

Authors: Michelerio A, Tomasini CF Abstract Alzheimer's disease (AD) is characterized by a cluster of signs and symptoms manifesting with difficulties in memory, language disturbances, psychological and psychiatric changes and difficulty in carrying out daily activities. Although it may seem to be far from a dermatologic competence, the ageing of populations in industrialized and developing countries has changed things making AD a multidisciplinary question. Indeed, this neurodegenerative disorder is not exclusively neurological, but rather may involve multiple tissues and organs. The abnormalities in metabolic and...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
FDA OCI, Dighton MA, Marietta Strickland, tampering, oxycodone, pain relief, Dighton Care and Rehabilitation Center, hospice patient, Alzheimer's, dementia, cancer, prescription drugs,
Source: Office of Criminal Investigations (OCI) Press Releases - Category: Medical Law Authors: Source Type: news
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Dear Carol: My father is 72 and is in the moderate stages of dementia. Before his dementia diagnosis, he was an active hunter and fisherman. He also has incontinence issues due to prostate cancer, surgery, and treatment. This requires an external urinary attachment system to maintain an active daily life. My mother, as his primary caregiver, works diligently to keep the system and attachments clean and in working order. However, he is at the stage in his dementia journey where he is not able to maintain this attachment on his own. Yet he is defiant when we try to explain that he cannot go on trips with friends because...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
WITHDRAWN
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Urology Source Type: research
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Dear Carol: My father is 72 and is in the moderate stages of dementia. Before his dementia diagnosis, he was an active hunter and fisherman. He also has incontinence issues due to prostate cancer, surgery, and treatment. This requires an external urinary attachment system to maintain an active daily life. My mother, as his primary caregiver, works diligently to keep the system and attachments clean and in working order. However, he is at the stage in his dementia journey where he is not able to maintain this attachment on his own. Yet he is defiant when we try to explain that he cannot go on trips with friends because...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
This very readable open access paper discusses some of the mechanisms involved in cardiovascular aging. As for many such publications, and to my eyes at least, it leans too much towards the details of the aged metabolism rather than towards the underlying causes that make the cells of an aged cardiovascular system behave differently. Near all medicine for age-related disease has so far focused on trying to change the way in which cells behave in response to the causes of aging, without addressing those causes, and, as a result, beneficial outcomes have been marginal at best. It is somewhere between very hard and impossible...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusions: The caregivers of patients with cancer or chronic severe illnesses experience high levels of fatigue: the longer the disease duration, the greater the degrees of depression, anxiety, and physical fatigue experienced by the caregivers. Such caregivers need strategies to manage their fatigue and depression. PMID: 32963657 [PubMed - in process]
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Background: Androgen deprivation therapy (ADT) is extensively used in prostate cancer. Yet the risk of impaired cognition or Alzheimer disease (AD) in men with prostate cancer receiving ADT is uncertain. Some studies of prostate cancer and ADT suggest that the risk of AD is not increased. But other studies have found an increased risk of AD and cognitive impairment. Objectives: As the uncertainty about ADT and dementia might relate to the genetics of prostate cancer and AD, the authors used the Cancer Genome Atlas (TCGA) to examine the relationship in men with prostate cancer between genes implicated in AD and genes i...
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Genitourinary Source Type: research
More News: Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Dementia | Geriatrics | Heart