Intravenous parecoxib for early postoperative cognitive dysfunction in elderly patients: evidence from a meta-analysis.

CONCLUSION: Perioperative parecoxib administration is effective in reducing the incidence of POCD and improving MMSE score compared with control. However, the beneficial effect of parecoxib has been tested only in Chinese population. Future RCTs in western countries with larger-scale and more comprehensive neurological tests are needed. PMID: 32077347 [PubMed - as supplied by publisher]
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Expert Rev Clin Pharmacol Source Type: research