Neuroprotective effects of miR-532-5p against ischemic stroke

In this study, we established anin vivo middle cerebral artery occlusion (MCAO) model in mice. The expression level of miR-532-5p, neurological score, infarct area, neuronal apoptosis, and phosphoinositide 3-kinase (PI3K)/Akt signaling pathway-related molecules were examined. Low miR-532-5p levels and high phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels were detected in the mouse MCAO model. MiR-532-5p overexpression improved neurological dysfunction, reduced the infarct area, attenuated neuronal injury and apoptosis, and promoted the activation of the PI3K/Akt signaling pathway in MCAO mice. In vitro, we treated mouse neuroblastoma cells (N2a) with oxygen-glucose deprivation and reperfusion (OGD/R). The expression level of miR-532-5p, cell viability, cell apoptosis, and the PI3K/Akt signaling pathway-related molecules were detected. Consistent with thein vivo tests, the miR-532-5p level was decreased and the PTEN level was increased in OGD-treated N2a cellsin vitro. The miR-532-5p mimic increased cell viability, decreased cell apoptosis, and activated the PI3K/Akt signaling pathway. Furthermore, PTEN was verified as a target gene of miR-532-5p by luciferase reporter assay. PTEN overexpression attenuated the protective effect of miR-532-5p in OGD-treated N2a cells. In summary, these findings reveal that miR-532-5p protects against ischemic stroke by inhibiting PTEN and activating the PI3K/Akt signaling pathway and may serve as a novel therapeutic target ...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research

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Publication date: Available online 31 March 2020Source: Journal of Sound and VibrationAuthor(s): Ge Yan, Hong-Xiang Zou, Sen Wang, Lin-Chuan Zhao, Qiu-Hua Gao, Ting Tan, Wen-Ming Zhang
Source: Journal of Sound and Vibration - Category: Physics Source Type: research
Authors: Matsumura E, Nohara K, Tanaka N, Fujii N, Sakai T Abstract Polypharmacy in elderly persons living at home or in a nursing home is an issue. In the field of dentistry, strategies to reduce polypharmacy must be promoted; however, there is insufficient basic data on medications received by elderly persons with dysphagia living at home or in a nursing home. The subjects were 106 elderly persons with dysphagia living at home or in a nursing home. Based on their medical records, the presence of disease and number/type of drugs being administered were investigated. Stroke, dementia, and hypertension were common. ...
Source: Journal of oral science - Category: Dentistry Tags: J Oral Sci Source Type: research
Schmalz, Gerhard / Farack, Mathias / Kottmann, Tanja / Schmidt, Jana / Krause, Felix / Ziebolz, DirkPage 139 - 144Purpose: The aim of this retrospective cross-sectional study was to detect dental health and dental treatment under general anaesthesia, as well as associations to selected parameters in a patient cohort with different disabilities.Material and Methods: Patients with disabilities, including mental, physical, combination of mental and physical as well as psychiatric disability, which received dental rehabilitation under general anaesthesia between 1 January 2002 and 31 December 2011 were included. Based on the a...
Source: Oral health and Preventive dentistry - Category: Dentistry Source Type: research
Doctors have observed neurological symptoms, including confusion, stroke and seizures, in a small subset of Covid-19 patients.
Source: NYT Health - Category: Consumer Health News Authors: Tags: your-feed-science Seizures (Medical) Coronavirus (2019-nCoV) Fever Senses and Sensation Nerves and Nervous System Smell (Olfaction) Boca Raton (Fla) China Europe Germany France Wuhan (China) United States your-feed-health Source Type: news
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Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Daily baths reduced the risk of heart disease and stroke.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Bathing and Showering Heart Blood Pressure Source Type: news
Condition:   Stroke Interventions:   Device: Robot-Assisted Hand Training;   Other: Standard Hand Therapy Sponsors:   National University Hospital, Singapore;   National University, Singapore Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Cerebral Small Vessel Diseases;   Cerebral Small Vessel Ischemic Disease;   Lacunar Stroke Interventions:   Diagnostic Test: 7 Tesla Magnetic Resonance Imaging;   Other: Brief Memory and Executive Test Sponsors:   University of Cambridge;   Cambridge University Hospitals NHS Foundation Trust;   Wolfson Brain Imaging Centre Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
I am a member of the New York State Task Force on Life and the Law and helped write its 2015 guidelines on the allocation of ventilators during a public health emergency. The position outlined by the Task Force report has been a point of confusion in the media. I don't believe that the Task Force recommendations discriminate against people with disabilities. The post Disabusing the Disability Critique of the New York State Task Force Report on Ventilator Allocation appeared first on The Hastings Center.
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care disability Discrimination Hastings Bioethics Forum Health and Health Care New York Task Force on Life and the Law syndicated ventilator allocation Source Type: blogs
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Source: Frontiers in Neurology - Category: Neurology Source Type: research
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