Fluoxetine exposure for more than 2 days decreases the neuronal plasticity mediated by CRMP2 in differentiated PC12 cells.

CONCLUSIONS: The results demonstrated that neuronal plasticity was increased by FLU exposure at day 1, but exposure with FLU for more than 2 days had opposite effect on it. The reduction in neuronal plasticity with FLU exposure for more than 2 days might be involved in some aspects of the therapeutic effect of antidepressant on depression. PMID: 32070769 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32070769?dopt=Abstract

Source: Brain Research Bulletin - February 14, 2020 Category: Neurology Authors: Wu Z, Wang G, Wang H, Xiao L, Wei Y, Yang C Tags: Brain Res Bull Source Type: research