Antivirals in medical biodefense

AbstractThe viruses historically implicated or currently considered as candidates for misuse in bioterrorist events are poxviruses, filoviruses, bunyaviruses, orthomyxoviruses, paramyxoviruses and a number of arboviruses causing encephalitis, including alpha- and flaviviruses. All these viruses are of concern for public health services when they occur in natural outbreaks or emerge in unvaccinated populations. Recent events and intelligence reports point to a growing risk of dangerous biological agents being used for nefarious purposes. Public health responses effective in natural outbreaks of infectious disease may not be sufficient to deal with the severe consequences of a deliberate release of such agents. One important aspect of countermeasures against viral biothreat agents are the antiviral treatment options available for use in post-exposure prophylaxis. These issues were adressed by the organizers of the 16th Medical Biodefense Conference, held in Munich in 2018, in a special session on the development of drugs to treat infections with viruses currently perceived as a threat to societies or associated with a potential for misuse as biothreat agents. This review will outline the state-of-the-art methods in antivirals research discussed and provide an overview of antiviral compounds in the pipeline that are already approved for use or still under development.
Source: Virus Genes - Category: Genetics & Stem Cells Source Type: research

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CONCLUSIONS: There is a need to improve respiratory infectious disease procedures in our study hospitals, especially in outpatient and emergency departments. PMID: 32459978 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Even with the relaxation of measures, pubs in the city are still likely to go to the wallTwo months after the Briton ’s Protection pub in Manchester city centre had to close its doors, the business’s owner Mark West doesn’t know when they will reopen, a source of frustration for him and his furloughed staff.The specialist ale and whisky pub, which has been serving the city ’s drinkers including artists and musicians for more than 200 years, is currently “haemorrhaging” money says West, who is using money from his property development business to support the pub.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak UK news Infectious diseases Medical research Microbiology Science Source Type: news
Cross-party group highlights new evidence on how dirty air may worsen infectionsCoronavirus – latest updatesSee all our coronavirus coverageAir pollution must be kept at low levels to help avoid a second peak of coronavirus infections, according to a cross-party report from MPs.There isgrowing evidence from around the world linking exposure to dirty air and increased infections and deaths from Covid-19. Lockdowns cut air pollution levels in many places, but the MPs said measures were needed to ensure it remains low.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Air pollution Coronavirus outbreak UK news US news Environment Science World news Politics Source Type: news
During the calamitous COVID-19 outbreak in Italy in April, some doctors and nurses who helped coronavirus patients chose to stay at a hotel and temporarily separate from their families.Reuters Health Information
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Infectious Diseases News Source Type: news
The objective of this study was to evaluate the genetic diversity of Moraxella bovis and Moraxella bovoculi bacteria isolated from infectious bovine keratoconjunctivitis (IBK) outbreaks in the state of Rio Grande do Sul, Brazil. The genetic diversity among Moraxella spp. was evaluated by RAPD-PCR, JWP1-JWOPA07-PCR, ERIC-PCR and by sequencing the 16S-23S intergenic regions. Based on the dendrogram, two genetically differentiated clades were observed; 14 isolates were classified as M. bovis and 17 as M. bovoculi. Genetic distances between the M. bovis samples ranged from 0.0379 to 0.4285, while for M. bovoculi the dissimilar...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
Scientists say failure to follow advice raises questions over test-and-trace policyCoronavirus – latest updatesSee all our coronavirus coverageOnly half of people who develop coronavirus symptoms self-isolate for at least a week, according to government science advisers, raising urgent questions about the success of the test, trace and isolate strategy needed to contain future outbreaks.In an April report to the government ’s Scientific Advisory Group on Emergencies (Sage), behavioural science experts said “rapid” research was needed on how best to get people to comply with self-isolation advice giv...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Science UK news Health policy Source Type: news
Conditions:   Bariatric Surgery Candidate;   Patient Underwent Bariatric Surgery Intervention:   Other: Telemedicine to remote outpatient visit in bariatric patient Sponsor:   University of Campania  " Luigi  Vanvitelli " Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Amgalan A, Othman M Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease in 2019 (COVID-19) which rapidly evolved from an outbreak in Wuhan, China into a pandemic that has resulted in over millions of infections and over hundreds of thousands of mortalities worldwide. Various coagulopathies have been reported in association with COVID-19, including disseminated intravascular coagulation (DIC), sepsis-induced coagulopathy (SIC), local microthrombi, venous thromboembolism (VTE), arterial thrombotic complications, and thrombo-inflammation. There is a...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
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Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Science UK news Older people Social care Society Health Source Type: news
A small molecule antiviral compound has been shown to protect rhesus monkeys against lethal Ebolavirus disease, even when given up to three days after virus inoculation. The compound, called GS-5734, is a nucleoside analog. After uptake into cells, GS-5734 is converted to a nucleoside triphosphate (illustrated, bottom panel) which is incorporated by the viral RNA dependent RNA polymerase as it copies the viral genome. However, the nucleoside is chemically different from ATP (illustrated, top) and no further nucleotides can be incorporated into the growing RNA strand. RNA synthesis ceases, blocking ...
Source: virology blog - Category: Virology Authors: Tags: Basic virology Information antiviral compound chain terminator ebolavirus nucleoside analog RNA polymerase rna synthesis viruses Source Type: blogs
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