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Personal Protective Equipment for Use in a Filovirus Disease Outbreak: Rapid Advice Guideline (November 2016)
World Health Organization. 11/2016 This 71-page document provides guidelines that are intended for health workers providing direct care to patients with known or suspected filovirus disease, and recommendations for use of personal protective equipment (PPE). Filoviruses (Ebola and Marburg) are highly contagious pathogens that cause severe and often fatal illness in humans. The risk of transmission of Ebola virus can be reduced if appropriate measures are taken, including the use of PPE. The document also includes a chapter on PPE in the framework of infection prevention and control, and health worker safety and well-being....
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - May 13, 2017 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

[This Week in Science] Fighting filoviruses with antibody therapy
Author: Lindsey Pujanandez (Source: ScienceNOW)
Source: ScienceNOW - April 7, 2017 Category: Science Authors: Lindsey Pujanandez Tags: Emerging Infections Source Type: news

Monoclonal antibody cures Marburg infection in monkeys
NIH-funded groups preparing for next filovirus outbreak. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - April 5, 2017 Category: American Health Source Type: news

WHO (World Health Organization) Target Product Profile for Multivalent Filovirus Vaccines: Providing Long-Term Protection to High-Risk Populations
World Health Organization. 11/2016 This 11-page document considers the prophylactic use of filovirus vaccines to protect high-risk groups whether before or during an outbreak of a public health emergency of international concern. These target groups comprise healthcare workers, frontline workers, and others at occupational risk, including potentially deployed international workers essential to assist in future outbreaks. The document provides guidance for prophylactic use only, where the primary objective of vaccination is individual protection and not interruption of transmission (reactive use). (PDF) (Source: Disaster Li...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - March 31, 2017 Category: Global & Universal Authors: The U.S. National Library of Medicine Source Type: news

A top 10 list waiting to save lives!
By Drs. David Niesel and Norbert Herzog Sometimes I have to remind myself we are in the 21st Century when I hear that infectious diseases are a leading cause of death among adults and remain the leading cause of death in children. While most of these deaths occur in the developing world, a significant number occur in middle income countries. Vaccines are the most cost effective medical intervention known to prevent infectious diseases. An effective vaccine can significantly reduce the mortality associated with them. However, while we have come a long way, the reality is that we have relatively few effective vaccines. O...
Source: Science - The Huffington Post - September 29, 2016 Category: Science Source Type: news

Ecologists identify potential new sources of Ebola and other filoviruses
An international team of ecologists has identified the bat species with the greatest potential to harbor filoviruses -- a family that includes Ebola virus. The researchers suggest that areas where many of these species overlap, notably in Southeast Asia, should be targeted for disease surveillance and virus discovery efforts. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 14, 2016 Category: Science Source Type: news

Artificial intelligence reveals undiscovered bat carriers of Ebola and other filoviruses
(Cary Institute of Ecosystem Studies) Barbara Han, a disease ecologist at the Cary Institute of Ecosystem Studies and the paper's lead author, comments, 'Using machine learning methods developed for artificial intelligence, we were able to bring together data from ecology, biogeography, and public health to identify bat species with a high probability of harboring Ebola and other filoviruses. Understanding which species carry these viruses, and where they are located, is essential to preventing future spillovers.' (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 14, 2016 Category: Infectious Diseases Source Type: news

Ecologists identify potential new sources of Ebola and other filoviruses
(University of Georgia) Worried about Ebola? Ecologists identify bats most likely to be filovirus carriers and map potential hotspots. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 14, 2016 Category: Infectious Diseases Source Type: news

Progress towards protection from highly lethal Ebola, Marburg viruses
Ebola and Marburg filovirus disease outbreaks have typically occurred as isolated events, confined to central Africa. However, the recent Ebola epidemic spread to several African countries, and caused 11,000 deaths. That epidemic underscored the need to develop vaccines and therapeutics that could be used to fight future disease outbreaks. Now new research suggests that antibodies to filoviruses from individuals who have survived these diseases may offer protection -- not only against the particular filovirus that infected an individual, but against other filoviruses, as well. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 12, 2016 Category: Science Source Type: news

Progress towards protection from highly lethal Ebola, Marburg viruses
(American Society for Microbiology) Ebola and Marburg filovirus disease outbreaks have typically occurred as isolated events, confined to central Africa. However, the recent Ebola epidemic spread to several African countries, and caused 11,000 deaths. That epidemic underscored the need to develop vaccines and therapeutics that could be used to fight future disease outbreaks. Now new research suggests that antibodies to filoviruses from individuals who have survived these diseases may offer protection -- not only against the particular filovirus that infected an individual, but against other filoviruses, as well. (Source: E...
Source: EurekAlert! - Infectious and Emerging Diseases - July 12, 2016 Category: Infectious Diseases Source Type: news

Filovirus Medical Countermeasures (MCM) Workshop
U.S. Department of Defense, Joint Program Executive Office for Chemical and Biological Defense. 10/23/2015This resource provides information, presentation slides, and transcripts from a workshop on filovirus medical countermeasures held on October 20-23, 2015. It featured a discussion about how to bridge nonclinical data to the human data, analysis of vaccine endpoints to support establishing a correlate of protection, and information about gaining a better understanding of the difference between the in vitro and in vivo models to test therapeutics. Other topics included vaccines, the Ebola outbreak, and FANG (Filovirus An...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - May 3, 2016 Category: Global & Universal Authors: The U.S. National Library of Medicine Source Type: news

Single-Vector, Single-Injection Recombinant Vesicular Stomatitis Virus Vaccines Against High-Containment Viruses
There are many avenues for making an effective vaccine against viruses. Depending on the virus these can include one of the following: inactivation of whole virions; attenuation of viruses; recombinant viral proteins; non-replication-competent virus particles; or surrogate virus vector systems such as vesicular stomatitis virus (VSV). VSV is a prototypic enveloped animal virus that has been used for over four decades to study virus replication, entry, and assembly due to its ability to replicate to high titers in a wide variety of mammalian and insect cells. The use of reverse genetics to recover infectious and single-cycl...
Source: Springer protocols feed by Immunology - April 8, 2016 Category: Allergy & Immunology Source Type: news

Blueprint for R&D Preparedness and Response to Public Health Emergencies Due to Highly Infectious Pathogens: Workshop on Prioritization of Pathogens
World Health Organization. 02/24/2016This seven-page document summarizes a meeting held on December 8-9, 2015, to prepare a process for prioritization of pathogens under the blueprint for accelerated R&D for severe emerging diseases with potential to generate a public health emergency, and for which no, or insufficient, preventive and curative solutions exist. Diseases requiring R&D include filovirus diseases (Ebola and Marburg), highly pathogenic emerging Coronaviruses relevant to humans (Middle East Respiratory Syndrome Coronavirus and SARS), chikungunya, and Zika virus. (PDF) (Source: Disaster Lit: Resource Guid...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - April 1, 2016 Category: Global & Universal Authors: The U.S. National Library of Medicine Source Type: news

An Online Survey to Assess Awareness of Ebola Virus Disease
Ebola virus disease (EVD) is a viral hemorrhagic fever caused by Ebola virus (EV). The virus belongs to the family Filoviridae and has a mortality rate of 20 to 90% in humans (1). Although EV was first discovered by Peter Piot following an outbreak of disease in 1976 (2), the 2014 epidemic has been much more extensive and disastrous. The reasons for such a significant death toll in the countries affected could be the low socioeconomic conditions that exist in the countries of endemicity, high rates of illiteracy, and overall unpreparedness in terms of facilities needed to provide care for the sick. (Source: Clinical Microbiology Newsletter)
Source: Clinical Microbiology Newsletter - July 24, 2015 Category: Microbiology Authors: Hindol Maity, Rithu Paul Stansilaus, Anjana Krishan, M. Riya, Vahid Rajabali Zadeh, Piya Paul Mudgal, Govindakarnavar Arunkumar Tags: Case Report Source Type: news

Frequently asked questions on Ebola virus disease
Ebola virus disease (formerly known as Ebola haemorrhagic fever) is a severe, often fatal illness, with a death rate of up to 90% caused by Ebola virus, a member of the filovirus family. The Ebola virus was first identified in 1976 when 2 simultaneous outbreaks occurred, 1 in Yambuku, a village not far from the Ebola River in the Democratic Republic of Congo and the other in a remote area of Sudan. (Source: WHO news on Ebola)
Source: WHO news on Ebola - July 14, 2015 Category: Infectious Diseases Tags: ebola [subject], ebola haemhorragic fever, ebola virus, ebola fever, ebola virus disease, ebola [subject], ebola haemhorragic fever, ebola virus, ebola fever, ebola virus disease, ebola [subject], ebola haemhorragic fever, ebola virus, ebola fever, ebola Source Type: news

A First Responder's Guide to Ebola
"Filoviridae is the only known virus family about which we have such profound ignorance." -- C.J. Peters & J.W. LeDuc, National Center for Infectious Diseases, CDC Learning Objectives Identify the signs and symptoms of Ebola. Learn the pathogenesis of Ebola. Understand how Ebola is transmitted and how to protect yourself when caring for an infected patient. KEY Terms Cytokine: Proteins important in cell signaling in immune response. Dendritic cells: Immune cells that encourage T-cell response. Macrophages: White blood cells that engulf foreign cells and assist in inflammation and immune processes. Tissue f...
Source: JEMS Patient Care - May 4, 2015 Category: Emergency Medicine Authors: James F. Goss, MHA, MICP Tags: Infectious Diseases Operations Provider Wellness & Safety Patient Care Source Type: news

Texas Biomed scientist receives up to $2.36 million NIH grant over 5 years to study new virus detection
(Texas Biomedical Research Institute) Scientists at Texas Biomedical Research Institute in San Antonio are receiving funding from the National Institutes of Health in the form of a $2.36 million R01 grant over the next five years to focus efforts on exploring and developing a novel mechanism of Filovirus detection -- using llama antibodies. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 9, 2015 Category: Infectious Diseases Source Type: news

Novavax Presents New Data From Non-Human Primate Ebola Challenge at the 7th International Symposium on Filoviruses
(Source: Medical News (via PRIMEZONE))
Source: Medical News (via PRIMEZONE) - March 28, 2015 Category: Pharmaceuticals Source Type: news

Yes, we can stop viruses such as Ebola and Rabies. Here's how.
(World Scientific) With a group of like-minded scientists, editors Asit K Pattanaik and Michael Whitt have compiled a timely publication entitled 'Biology and Pathogenesis of Rhabdo- and Filoviruses' discussing the most recent findings on processes and current status of development of vaccines and antivirals to mitigate the diseases caused by viruses like Ebola and Rabies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 27, 2015 Category: Global & Universal Source Type: news

Trial confirms Ebola vaccine candidate safe, equally immunogenic in Africa
Two experimental DNA vaccines to prevent Ebola virus and the closely related Marburg virus are safe, and generated a similar immune response in healthy Ugandan adults as reported in healthy US adults earlier this year. The findings are from the first trial of filovirus vaccines in Africa. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 23, 2014 Category: Science Source Type: news

Experimental Ebola vaccines are ruled safe
The first trial of filovirus vaccines in Africa has a positive response (Source: Telegraph Health)
Source: Telegraph Health - December 22, 2014 Category: Consumer Health News Source Type: news

Ebola modifies genes as it kills infected hosts
(NaturalNews) The mechanism by which Ebola and other filoviruses attack and kill their hosts has been identified as what we now know to be genetic modification, according to shocking new research published in the journal mBio. Upon entry, Ebola and the related Marburg viruses demonstrably... (Source: NaturalNews.com)
Source: NaturalNews.com - November 9, 2014 Category: Consumer Health News Source Type: news

Ebola, Marburg viruses edit genetic material during infection
(American Society for Microbiology) Filoviruses like Ebola 'edit' genetic material as they invade their hosts, according to a study published this week in mBio, the online open-access journal of the American Society for Microbiology. The work, by researchers at the Icahn School of Medicine at Mount Sinai, the Galveston National Laboratory, and the J. Craig Venter Institute, could lead to a better understanding of these viruses, paving the way for new treatments down the road. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 4, 2014 Category: Infectious Diseases Source Type: news

Research Priorities to Inform Public Health and Medical Practice for Domestic Ebola Virus Disease (EVD): A Workshop
November 3, 2014, Washington, DC. This one-day workshop that will explore potential research priorities arising as a result of the emergence of Ebola Virus Disease (EVD), a hemorrhagic disease caused by a filovirus, in the United States. The workshop will be available by webcast. (Source: PHPartners.org)
Source: PHPartners.org - October 30, 2014 Category: Global & Universal Source Type: news

Workshop on public health research for Ebola
(National Academy of Sciences) An ad hoc committee, under the auspices of the Institute of Medicine in collaboration with the National Research Council will organize a one-day workshop that will explore potential research priorities arising as a result of the emergence of Ebola Virus Disease, a hemorrhagic disease caused by a filovirus, in the United States. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 15, 2014 Category: Global & Universal Source Type: news

Ebola vaccine hope after successful animal study
Conclusion This study has shown the potential of a new vaccine for Ebola virus in chimpanzees. Interest in the quest for a vaccine is seen as urgent, due to the ongoing outbreak of Ebola in West Africa. Animal studies such as this are needed to ensure that any new vaccines are safe, and that they look like they will have an effect. Macaques were used for this research because they, like humans, are primates – therefore, their responses to the vaccine should be similar to what would be expected in humans. Now that these tests have shown promising results, the first human trials have started in the US, accor...
Source: NHS News Feed - September 8, 2014 Category: Consumer Health News Tags: Medical practice Medication Source Type: news

Experimental Treatment for Marburg Virus Shows Promise in Primates (FREE)
By Kelly Young Edited by Susan Sadoughi, MD An experimental treatment resulted in 100% survival in primates infected with Marburg virus, a filovirus — like Ebola — that causes hemorrhagic fever, according to a study in Science … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - August 21, 2014 Category: Primary Care Source Type: news

Ebola Hemorrhagic Fever Information
Ebola hemorrhagic fever or, ‘Ebola HF,’ is one of a number of Viral Hemorrhagic Fevers. It is a severe and many times fatal disease in people and non-human primates such as gorillas, chimpanzees, and monkeys. Ebola HF is caused by infection with a virus of the family, ‘Filoviridae,’ genus Ebolavirus. When an infection happens, symptoms usually start quickly. (Source: Disabled World)
Source: Disabled World - April 17, 2014 Category: Disability Tags: Health and Disability Source Type: news

International research group recognizes UTMB experts
(University of Texas Medical Branch at Galveston) The global experts who study the deadliest infectious diseases recognized the contributions of Frederick A. Murphy and Thomas G. Ksiazek, professors at the University of Texas Medical Branch, with a Lifetime Achievement Award at the 6th annual International Symposium on Filoviruses. The filoviruses include Ebola and Marburg viruses that cause death in 50 to 90 percent of people infected. The current outbreak of Ebola virus raging in West Africa has caused more than 100 deaths so far. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 15, 2014 Category: Biology Source Type: news

Light zaps viruses: How photosensitization can stop viruses from infecting cells
A UCLA-led team of researchers has found evidence that photosensitizing a virus's membrane covering can inhibit its ability to enter cells and potentially lead to the development of stronger, cheaper medications to fight a host of tough viruses.   The UCLA AIDS Institute study, published in the February issue of the Journal of Virology, is part of ongoing research on a compound called LJ001, a "broad-spectrum" antiviral that can attack a wide range of microbes.   The current paper advances the science by showing that the process of photosensitization — heightening a biological organism's sens...
Source: UCLA Newsroom: Health Sciences - February 28, 2014 Category: Universities & Medical Training Source Type: news