Marburg virus disease: origins, reservoirs, transmission and guidelines
Marburg virus is a Filovirus which, along with Ebola virus, can cause a severe and often fatal viral haemorrhagic fever (VHF). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 24, 2023 Category: Consumer Health News Source Type: news
Marburg virus outbreak: Tanzania announces spread of deadly disease
Tanzania has announced its first-ever cases of Marburg virus disease, a deadly infection that has a fatality rate of around 50 percent. The World Health Organization (WHO) said in a statement that Tanzania's National Public Health Laboratory has confirmed that eight people so have contracted the…#tanzania #equatorialguinea #nipah #filoviridae #thomasgeisbert #galveston #belgrade #serbia #frankfurt #marburg (Source: Reuters: Health)
Source: Reuters: Health - March 23, 2023 Category: Consumer Health News Source Type: news
Merck locates frozen batch of undisclosed Ebola vaccine, will donate for testing in Uganda ’s outbreak
In a revelation that may help Uganda combat its outbreak of Ebola, the pharmaceutical giant Merck has acknowledged to
Science—
after repeated inquiries
—
that it has up to 100,000 doses of an experimental vaccine for the deadly viral disease in its freezers in Pennsylvania and will donate them. The World Health Organization (WHO) and the Ugandan government are discussing if and how these doses can be incorporated into one or more clinical trials of
other
candidate Ebola vaccines that could launch as soon as next month.
The Merck vaccine targets Sudan ebolavirus, the pathogen currentl...
Source: ScienceNOW - October 23, 2022 Category: Science Source Type: news
Janssen Announces Novel Mechanism of Action that Shows Promise Against Dengue in Data Published in Nature
BEERSE, BELGIUM, October 6, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson (Janssen) announced today, in collaboration with the KU Leuven Rega Institute and the KU Leuven Centre for Drug Design and Discovery (CD3), the publication of new preclinical data in the journal Nature showing that an early-stage compound with a novel mechanism of action could potentially treat all serotypes of dengue fever and provide a period of protection against acquiring the dengue virus. Janssen is now moving its dengue program into clinical development. Data from the early-stage study suggest that an antiviral compound...
Source: Johnson and Johnson - October 6, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Ebola is a master of disguise
(University of Ottawa) Ebola is so pernicious because it pulls a fast one on the body, disguising itself as a dying cell. A study published in the journal PLOS Pathogens, identifies a pathway that all filoviruses use to gain entry into our cells--and shows how they can be stopped in their tracks by at least one FDA-approved drug. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 11, 2021 Category: International Medicine & Public Health Source Type: news
New drug target for Ebola, Marburg viruses
(University of Illinois at Chicago) Researchers have identified a previously unknown site on the filovirus glycoprotein to which small drug molecules can bind and prevent infection -- blocking both sites may be a more effective treatment while reducing the risk of side effects. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 8, 2021 Category: Infectious Diseases Source Type: news
Johnson & Johnson Announces European Commission Approval for Janssen ’s Preventive Ebola Vaccine
Discussions with the U.S. Food and Drug Administration (FDA) have taken place to define the required data set for filing US licensure. About Janssen’s Ebola Vaccine Regimen The Janssen preventive Ebola vaccine regimen, Ad26.ZEBOV and MVA-BN-Filo, utilizes a non-replicating viral vector strategy in which viruses – in this case adenovirus serotype 26 (Ad26) and Modified Vaccinia Virus Ankara (MVA) – are genetically modified so that they cannot replicate in human cells. In addition, these vectors carry the genetic code of several Ebola virus proteins in order to trigger an immune response.Janssen’s vaccine regimen ori...
Source: Johnson and Johnson - July 1, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news
Researchers show how Ebola virus hijacks host lipids
(Biophysical Society) Robert Stahelin studies some of the world's deadliest viruses. Filoviruses, including Ebola virus and Marburg virus, cause viral hemorrhagic fever with high fatality rates. Stahelin, professor at Purdue University, examines how these viruses take advantage of human host cells. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 15, 2020 Category: Infectious Diseases Source Type: news
Public Health Emergency Medical Countermeasures Enterprise Multiyear Budget: Fiscal Years 2018-2022
This report describes the five-year interagency budget plan for the basic research, advanced research and development, regulatory review, procurement, stockpiling, and replenishment of the U.S. government ’s civilian medical countermeasure enterprise for Fiscal Years 2018-2022. It describes estimated spending by threat for the cumulative five-year period and the change relative to the last year’s report, including for pandemic and seasonal influenza; broad spectrum antimicrobials; filoviruses, in cluding Ebola; and chemical, nuclear, and radiological threats.
(Text) (Source: Disaster Lit: Resource Guide for Disaster Me...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - December 1, 2019 Category: International Medicine & Public Health Source Type: news
Evidence of cross-species filovirus transmission from bats to humans
(Duke-NUS Medical School) Virus spillover may be occurring between bats and humans in Nagaland, India, according to a new collaborative study by the National Centre of Biological Sciences (NCBS) in India, Duke-NUS Medical School in Singapore, and the Uniformed Services University of the Health Sciences (USUHS) in the USA. The study published in the scientific journal PLOS Neglected Tropical Diseases, reaffirms the importance of virus surveillance at wildlife and human interfaces where the risk of virus spillover (transmission) may be highest. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 31, 2019 Category: Infectious Diseases Source Type: news
Ebola in Zaire, 1976: The Past as Prologue
Source: Centers for Disease Control and Prevention (CDC). Published: 9/5/2019.
This one-hour, 29-minute lecture, part of the Centers for Disease Control and Prevention (CDC) Office of Science “We Were There” series, details how disease detectives discovered the Ebola virus in 1976 in Zaire (now the Democratic Republic of the Congo), and how the understanding of it has grown with subsequent outbreaks over the past 40 years. Samples of the unidentified disease in that outbreak yielded alarming images of a filovirus resembling Marburg, but serology testing at the CDC showed a new virus, later named Ebola.
(Video or Mult...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - September 5, 2019 Category: International Medicine & Public Health Source Type: news
Pan-filovirus T-cell vaccine protects mice from Ebola and Marburg
(PLOS) Vaccines that induce protective T-cell responses could protect against members across the filovirus family, according to a study published Feb. 28 in the open-access journal PLOS Pathogens by Tom á Hanke of the University of Oxford, Bette Korber of the Los Alamos National Laboratory, and colleagues (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 28, 2019 Category: Infectious Diseases Source Type: news
Duke-NUS researchers discover new bat-borne virus related to Ebola
(Duke-NUS Medical School) A new genus of filovirus from a species of bat has been discovered by researchers studying emerging infectious diseases. The virus--a relative of Ebola--may be capable of infecting many other species, including humans. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 7, 2019 Category: International Medicine & Public Health Source Type: news
New bat-borne virus related to Ebola discovered by Singapore team
(Duke University Medical Center) Newly discovered Mengla virus is evolutionarily closely related to Ebola virus and Marburg virus and shares several important functional similarities with them. For example, the genome organisation of the Mengl à virus is consistent with other filoviruses, coding for seven genes. The Mengl à virus also uses the same molecular receptor, a protein called NPC1, as Ebola virus and Marburg virus to gain entry into cells and cause infection. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 7, 2019 Category: International Medicine & Public Health Source Type: news
WHO (World Health Organization) Emergency Quality Assessment Mechanism for EVD (Ebola Virus Disease) IVDs (In Vitro Diagnostics): Public Report; Product: RealStar ® Filovirus Screen RT-PCR Kit 1.0 (2019)
Source: World Health Organization (WHO). Published: 1/2019.
This 41-page document describes the 2019 updated emergency quality assessment mechanism for Ebola virus disease in vitro diagnostics for RealStar ® Filovirus Screen RT-PCR Kit 1.0. This product is a manual in vitro diagnostic test, based on real-time PCR technology, for the qualitative detection and differentiation of Ebola- and Marburg virus- specific RNA in human EDTA plasma.
(PDF) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - January 1, 2019 Category: International Medicine & Public Health Source Type: news
