Berberine promotes XIAP-mediated cells apoptosis by upregulation of miR-24-3p in acute lymphoblastic leukemia.

CONCLUSIONS: miR-24-3p/PIM-2/XIAP signaling contributes to BBR-mediated leukemia mitigation in p53-defect ALL, which should be further developed as a treatment strategy in ALL patients with p53 deficiency.
METHODS: Cell viability and apoptosis were determined using CCK-8 and TUNEL assays, respectively. The dual-luciferase reporter gene system was used to determine the interaction between miR-24-3p and 3'-untranslated regions (UTRs) of PIM-2.
PMID: 32062612 [PubMed - as supplied by publisher]

Source: Aging - February 12, 2020 Category: Biomedical Science Authors: Liu J, Chen Z, Cui Y, Wei H, Zhu Z, Mao F, Wang Y, Liu Y Tags: Aging (Albany NY) Source Type: research